Results 11 to 20 of about 55,484 (212)
Design principles for ligand-sensing, conformation-switching ribozymes. [PDF]
PLoS Computational Biology, 2009 Nucleic acid sensor elements are proving increasingly useful in biotechnology and biomedical applications. A number of ligand-sensing, conformational-switching ribozymes (also known as allosteric ribozymes or aptazymes) have been generated by some ...
Xi Chen, Andrew D Ellington
doaj +1 more source
Viral genome structures are optimal for capsid assembly
eLife, 2013 Understanding how virus capsids assemble around their nucleic acid (NA) genomes could promote efforts to block viral propagation or to reengineer capsids for gene therapy applications.
Jason D Perlmutter +2 more
doaj +1 more source
Nucleic acid-lipid membrane interactions studied by DSC
Journal of Pharmacy and Bioallied Sciences, 2011 The interactions of nucleic acids with lipid membranes are of great importance for biological mechanisms as well as for biotechnological applications in gene delivery and drug carriers. The optimization of liposomal vectors for clinical use is absolutely
Sarantis Giatrellis, George Nounesis
doaj +1 more source
Origin of Information Encoding in Nucleic Acids through a Dissipation-Replication Relation [PDF]
Entropy 2020, 22(9), 940, 2018 Ultraviolet light incident on organic material can initiate its spontaneous dissipative structuring into chromophores which can then catalyze their own replication. This may have been the case for one of the most ancient of all chromophores dissipating the Archean UVC photon flux, the nucleic acids.
arxiv +1 more source
Preferential interaction coefficient for nucleic acids and other cylindrical poly-ions [PDF]
Macromolecules 40, 1305 (2007), 2007 The thermodynamics of nucleic acid processes is heavily affected by the electric double-layer of micro-ions around the polyions. We focus here on the Coulombic contribution to the salt-polyelectrolyte preferential interaction (Donnan) coefficient and we report extremely accurate analytical expressions valid in the range of low salt concentration (when ...
arxiv +1 more source
BioTechniques, 2008 A rapid capture technique was developed to efficiently isolate specific DNA targets from a variety of genomes. The specificity can be easily adapted to any target for which partial sequence is known, allowing for the isolation of a wide set of target ...
Judy St. John, Thomas W. Quinn
doaj +1 more source
Studying epigenetic interactions using MicroScale Thermophoresis (MST)
AIMS Biophysics, 2015 Epigenetic regulation is based on specific molecular interactions between epigenetic reader, writer and eraser molecules and chromatin. Binding parameters of these interactions such as binding affinities, stoichiometries and thermodynamics are essential ...
Thomas Schubert, Gernot Längst
doaj +1 more source
An efficient algorithm for the stochastic simulation of the hybridization of DNA to microarrays
BMC Bioinformatics, 2009 Background Although oligonucleotide microarray technology is ubiquitous in genomic research, reproducibility and standardization of expression measurements still concern many researchers. Cross-hybridization between microarray probes and non-target ssDNA
Laurenzi Ian J, Arslan Erdem
doaj +1 more source
Chemistry – A European Journal, Volume 28, Issue 69, December 9, 2022., 2022 Getting back to (nucleo)base: Oligonucleotides incorporating a central 1‐ or 8‐mercuri‐6‐phenyl‐1H‐carbazole residue show great promise as high‐affinity hybridization probes, discriminating between all canonical nucleobases as well as 2‐ and 4‐thiothymines by melting temperature margins of at least 5 °C.
Tharun K. Kotammagari +2 more
wiley +1 more source
BMC Bioinformatics, 2007 Background RNA interference (RNAi) is a naturally occurring phenomenon that results in the suppression of a target RNA sequence utilizing a variety of possible methods and pathways.
Peek Andrew S
doaj +1 more source