Results 11 to 20 of about 9,650,806 (331)
Slow wave activity across sleep-night could predict levodopa-induced dyskinesia
Scientific Reports, 2023 A disruption in the slow wave activity (SWA) mediated synaptic downscaling process features Parkinson's disease (PD) patients presenting levodopa-induced dyskinesia (LID).
Ninfa Amato +5 more
doaj +1 more source
Familial Parkinson’s Disease/Parkinsonism [PDF]
BioMed Research International, 2015 Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by parkinsonism (bradykinesia, resting tremor, rigidity, and postural instability) with good response to L-dopa. Although the majority of PD patients are sporadic, it is now clear that genetic factors contribute to the pathogenesis of PD.
Hiroyuki Tomiyama +3 more
openaire +2 more sources
Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease
Nature Communications, 2023 Little is known about circular RNAs (circRNAs) in specific brain cells and human neuropsychiatric disease. Here, we systematically identify over 11,039 circRNAs expressed in vulnerable dopamine and pyramidal neurons laser-captured from 190 human brains ...
Xianjun Dong +11 more
doaj +1 more source
Discriminating α-synuclein strains in Parkinson’s disease and multiple system atrophy
Nature, 2020 Mohammad Shahnawaz +2 more
exaly +2 more sources
Patient-Centric Care for Parkinson's Disease: From Hospital to the Community
Frontiers in Neurology, 2020 Parkinson's disease (PD) is a chronic neurodegenerative disease with complex motor and non-motor symptoms often leading to significant caregiver burden.
Yin Minn Aye +27 more
doaj +1 more source
Postgraduate Medical Journal, 1997 Summary Parkinson's disease is a common disabling disease of old age. The diagnosis of idiopathic Parkinson's disease is based on clinical signs and has poor sensitivity, with about 25% of patients confidently diagnosed as having the disease actually having other conditions such as multi-system atrophy and other parkinsonism-plus ...
E R, Barbosa +2 more
+7 more sources
Incidence of Parkinson disease in North America
npj Parkinson's Disease, 2022 Parkinson disease (PD) is the second most common age-related neurodegenerative condition diagnosed in North America. We recently demonstrated, using multiple epidemiological data sources, that the prevalence of PD diagnoses was greater than previously ...
A. Willis +16 more
semanticscholar +1 more source
Human Molecular Genetics, 2007 Parkinson's disease (PD) is a chronic progressive neurodegenerative movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic neurons. Clinical manifestations of this complex disease include motor impairments involving resting tremor, bradykinesia, postural instability, gait difficulty and rigidity.
Bobby, Thomas, M Flint, Beal
openaire +5 more sources
Differential serum microRNAs in premotor LRRK2 G2019S carriers from Parkinson’s disease
npj Parkinson's Disease, 2023 The LRRK2 G2019S pathogenic mutation causes LRRK2-associated Parkinson’s disease (L2PD) with incomplete penetrance. LRRK2 non-manifesting carriers (L2NMC) are at PD high risk but predicting pheno-conversion is challenging given the lack of progression ...
Marta Soto +17 more
doaj +1 more source
Transcriptome analysis in LRRK2 and idiopathic Parkinson’s disease at different glucose levels
npj Parkinson's Disease, 2021 Type-2 diabetes (T2D) and glucose metabolic imbalances have been linked to neurodegenerative diseases, including Parkinson’s disease (PD). To detect potential effects of different glucose levels on gene expression, by RNA-seq we analyzed the ...
Rubén Fernández-Santiago +9 more
doaj +1 more source