Results 11 to 20 of about 69,899 (93)

The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability

Mediators of Inflammation, 2020
Matrix metalloproteinase-9 (MMP-9) belongs to the MMP family and has been widely investigated. Excessive MMP-9 expression can enhance extracellular matrix degradation and promote plaque instability.
Tiewei Li, Xiaojuan Li, Yichuan Feng, Geng Dong, Yuewu Wang, Junmei Yang   +5 more
doaj   +1 more source

Localization of lipopolysaccharide from Escherichia Coli into human atherosclerotic plaque [PDF]

, 2018
Experimental studies showed that gut-derived lipopolysaccharide (LPS) is pro-atherogenic, however, its relationship with human atherosclerosis is still to be defined.
Cammisotto, Vittoria, Carnevale, Roberto, Frati, Giacomo, Irace, Luigi, Martinelli, Ombretta, Nocella, Cristina, Pacini, Luca, Pastori, Daniele, Petrozza, Vincenzo, Sciarretta, Sebastiano, Sorrentino, Veronica, Violi, Francesco   +11 more
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Research Progress on the Risk Factors and Outcomes of Human Carotid Atherosclerotic Plaques

Chinese Medical Journal, 2017
Objective: Atherosclerosis is an inflammatory process that results in complex lesions or plaques that protrude into the arterial lumen. Carotid atherosclerotic plaque rupture, with distal atheromatous debris embolization, causes cerebrovascular events ...
Xiang-Dong Xiong, Wei-Dong Xiong, Shang-Shen Xiong, Gui-Hai Chen   +3 more
doaj   +1 more source

Atherosclerotic carotid plaque composition: a 3T and 7T MRI-histology correlation study [PDF]

, 2016
Background and Purpose Carotid artery atherosclerotic plaque composition may influence plaque stability and risk of thromboembolic events, and non-invasive plaque imaging may therefore permit risk stratification for clinical management.
Condon, B., Foo, S.Y., Forbes, K.P., Holmes, W.M., Lopez Gonzalez, M.R., Muir, K.W., Stewart, W., Welch, G.   +7 more
core   +1 more source

Intermedin1-53 attenuates atherosclerotic plaque vulnerability by inhibiting CHOP-mediated apoptosis and inflammasome in macrophages

Cell Death and Disease, 2021
Atherosclerotic plaque vulnerability and rupture increase the risk of acute coronary syndromes. Advanced lesion macrophage apoptosis plays important role in the rupture of atherosclerotic plaque, and endoplasmic reticulum stress (ERS) has been proved to ...
Jin-Ling Ren, Yao Chen, Lin-Shuang Zhang, Ya-Rong Zhang, Shi-Meng Liu, Yan-Rong Yu, Mo-Zhi Jia, Chao-Shu Tang, Yong-Fen Qi, Wei-Wei Lu   +9 more
doaj   +1 more source

Comparative study on hemodynamic environments around patient-specific carotid atherosclerotic plaques with different symmetrical features

Medicine in Novel Technology and Devices, 2021
Atherosclerotic plaque near the carotid sinus is a key risk factor for ischemic stroke. Although disturbed hemodynamic environments around atherosclerotic plaque had been investigated in many studies, the effect of their symmetrical features, especially ...
Xianghui Gong, Zhuqing Liang, Yawei Wang, Chi Zhang, Sheng Xie, Yubo Fan   +5 more
doaj   +1 more source

Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]

, 2011
Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne, Rutsch, Frank, Terkeltaub, Robert, Weissen-Plenz, Gabriele   +3 more
core   +1 more source

Roles of reconstituted high-density lipoprotein nanoparticles in cardiovascular disease: A new paradigm for drug discovery [PDF]

, 2020
Epidemiological results revealed that there is an inverse correlation between high-density lipoprotein (HDL) cholesterol levels and risks of atherosclerotic cardiovascular disease (ASCVD).
Huang, Hui, Huang, Jiansheng, Huang, Li-Hao, Wang, Dongdong   +3 more
core   +2 more sources

Exploiting macrophage autophagy-lysosomal biogenesis as a therapy for atherosclerosis [PDF]

, 2017
Macrophages specialize in removing lipids and debris present in the atherosclerotic plaque. However, plaque progression renders macrophages unable to degrade exogenous atherogenic material and endogenous cargo including dysfunctional proteins and ...
Ali, Sahl, Ballabio, Andrea, Bhattacharya, Somashubhra, Crowley, Jan R, Dehestani, Babak, Diwan, Abhinav, Epelman, Slava, Evans, Trent D, Fan, Daping, Holloway, Karyn B, Javaheri, Ali, Micevych, Paul S, Razani, Babak, Schilling, Joel D, Sergin, Ismail, Song, Eric, Stokes, Carl J, Weihl, Conrad C, Zayed, Mohamed A, Zhang, Xiangyu   +19 more
core   +2 more sources

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor-Deficient Mice [PDF]

, 2008
Objective—Atherosclerosis is a vascular disease that involves lesion formation at sites of disturbed flow under the influence of genetic and environmental factors.
Arora, Shikha, Boylan, Brian, Fleming, Barbara, Fleming, Rose Ann, Goel, Reema, Mirura, Hiroto, Molthen, Robert C., Newman, Debra K., Newman, Peter J., Schrank, Benjamin R.   +9 more
core   +2 more sources