Results 11 to 20 of about 54,063 (260)

Propranolol blocks osteosarcoma cell cycle progression, inhibits angiogenesis and slows xenograft growth in combination with cisplatin-based chemotherapy

Scientific Reports, 2022
Osteosarcoma is still associated with limited response to standard-of-care therapy and alarmingly elevated mortality rates, especially in low- and middle-income countries.
Luisina M. Solernó, Natasha T. Sobol, María F. Gottardo, Carla S. Capobianco, Maximiliano R. Ferrero, Liliana Vásquez, Daniel F. Alonso, Juan Garona   +7 more
doaj   +1 more source

The Anti-Virulence Activities of the Antihypertensive Drug Propranolol in Light of Its Anti-Quorum Sensing Effects against Pseudomonas aeruginosa and Serratia marcescens

Biomedicines, 2023
The development of bacterial resistance is an increasing global concern that requires discovering new antibacterial agents and strategies. Bacterial quorum sensing (QS) systems play important roles in controlling bacterial virulence, and their targeting ...
Hadil Faris Alotaibi, Haifa Alotaibi, Khaled M. Darwish, El-Sayed Khafagy, Amr S. Abu Lila, Mohamed A. M. Ali, Wael A. H. Hegazy, Samar Zuhair Alshawwa   +7 more
doaj   +1 more source

Successful and safe treatment of hemangioma with oral propranolol in a single institution [PDF]

Korean Journal of Pediatrics, 2012
PurposeDramatic improvement of hemangioma to propranolol has been recently reported; however, details on dose and duration of treatment, potential risks, and monitoring have not been determined.
Sun Hee Chung, Dong Hyuk Park, Hye Lim Jung, Jae Won Shim, Deok Soo Kim, Jung Yeon Shim, Moon Soo Park, Hong Hoe Koo   +7 more
doaj   +1 more source

Analysis of drug interactions with serum proteins and related binding agents by affinity capillary electrophoresis: A review

ELECTROPHORESIS, Volume 43, Issue 23-24, Page 2302-2323, December 2022., 2022
Abstract Biomolecules such as serum proteins can interact with drugs in the body and influence their pharmaceutical effects. Specific and precise methods that analyze these interactions are critical for drug development or monitoring and for diagnostic purposes.
Sadia Sharmeen, Isaac Kyei, Arden Hatch, David S. Hage   +3 more
wiley   +1 more source

Efficacy of Combined Topical Timolol and Oral Propranolol for Treating Infantile Hemangioma: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Pharmacology, 2020
BackgroundOral propranolol has become the first-line treatment for infantile hemangioma (IH). However, combined therapy with topical timolol and oral propranolol has been proposed as a more effective IH treatment strategy.
Junbo Qiao, Junjie Lin, Dexin Zhang, Junhua Li, Changkuan Chen, Hongye Yu, Xiaodi Li, Bin Fang   +7 more
doaj   +1 more source

Splanchnic Venous Compression Enhances the Effects of ß‐Blockade in the Treatment of Postural Tachycardia Syndrome

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Splanchnic venous pooling induced by upright posture triggers a compensatory increase in heart rate (HR), a response that is exaggerated in patients with postural tachycardia syndrome.
Emily C. Smith, André Diedrich, Satish R. Raj, Alfredo Gamboa, Cyndya A. Shibao, Bonnie K. Black, Amanda Peltier, Sachin Y. Paranjape, Italo Biaggioni, Luis E. Okamoto   +9 more
doaj   +1 more source

Propranolol Sensitizes Vascular Sarcoma Cells to Doxorubicin by Altering Lysosomal Drug Sequestration and Drug Efflux

Frontiers in Oncology, 2021
Angiosarcoma is a rare cancer of blood vessel–forming cells with a high patient mortality and few treatment options. Although chemotherapy often produces initial clinical responses, outcomes remain poor, largely due to the development of drug resistance.
Jhuma Saha, Jong Hyuk Kim, Jong Hyuk Kim, Jong Hyuk Kim, Clarissa N. Amaya, Clarissa N. Amaya, Caleb Witcher, Ali Khammanivong, Derek M. Korpela, David R. Brown, Josephine Taylor, Brad A. Bryan, Brad A. Bryan, Erin B. Dickerson, Erin B. Dickerson, Erin B. Dickerson   +15 more
doaj   +1 more source

Mass spectrometry in ocular drug research

Mass Spectrometry Reviews, EarlyView., 2023
Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo, Kati‐Sisko Vellonen, Arto Urtti, Tetsuya Terasaki, Anam Hammid, Paavo Honkakoski, Seppo Auriola   +6 more
wiley   +1 more source

Facile Synthesis of Propranolol and Novel Derivatives

Journal of Chemistry, 2020
Propranolol is one of the first medications of the beta-blocker used for antihypertensive drugs. This study reports the facile route for the synthesis of propranolol and its novel derivatives.
Vy Anh Tran, Nguyen Hai Tai Tran, Long Giang Bach, Trinh Duy Nguyen, Thi Thuong Nguyen, Tan Tai Nguyen, Thi Anh Nga Nguyen, The Ky Vo, Thu-Thao Thi Vo, Van Thuan Le   +9 more
doaj   +1 more source

Combinative effects of β-elemene and propranolol on the proliferation, migration, and angiogenesis of hemangioma [PDF]

PeerJ, 2023
Hemangioma (HA) is one of the most common benign vascular tumors among children. Propranolol is used as the first-line treatment for hemangioma and is a non-selective blocker of the β-adrenergic receptor.
Zhenyu Wang, Yinxian Chen, Lin Yang, Dunbiao Yao, Yang Shen   +4 more
doaj   +2 more sources