Tropoelastin and Elastin Assembly [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Elastic fibers are an important component of the extracellular matrix, providing stretch, resilience, and cell interactivity to a broad range of elastic tissues.
Jazmin Ozsvar +9 more
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Tropoelastin Promotes the Formation of Dense, Interconnected Endothelial Networks [PDF]
Biomolecules, 2021 Tropoelastin, the soluble precursor of elastin, has been used for regenerative and wound healing purposes and noted for its ability to accelerate wound repair by enhancing vascularization at the site of implantation.
Aleen Al Halawani +3 more
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The Matrix Protein Tropoelastin Prolongs Mesenchymal Stromal Cell Vitality and Delays Senescence During Replicative Aging [PDF]
Advanced ScienceCellular senescence leads to the functional decline of regenerative cells such as mesenchymal stromal/stem cells (MSCs), which gives rise to chronic conditions and contributes to poor cell therapy outcomes. Aging tissues are associated with extracellular
Sunny Shinchen Lee +4 more
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Evolutionary constraints on positional sequence, collective properties and sequence style of tropoelastin dictated by fundamental requirements for formation and function of the extracellular elastic matrix [PDF]
Matrix Biology PlusElastin is the extracellular matrix protein responsible for properties of extension and energy-efficient elastic recoil in large blood vessels, lung parenchyma and other vertebrate tissues.
Fred W. Keeley
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Bioactive Materials, 2022 Intra-articular injection of mesenchymal stem cells (MSCs) is a promising strategy for osteoarthritis (OA) treatment. However, more and more studies reveal that the injected MSCs have poor adhesion, migration, and survival in the joint cavity.
Junjun Yang +15 more
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Tropoelastin Improves Post-Infarct Cardiac Function [PDF]
Circulation Research, 2023 Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may have more favorable properties within the cardiac scar.
Robert D. Hume +17 more
semanticscholar +4 more sources
Isoform-specific oxidative modifications of tropoelastin by HOCl and MPO alter protein self-assembly [PDF]
Redox ReportBackground Tropoelastin (TE), the soluble precursor of elastin, is critical for the elasticity of arteries, lungs, and skin. Oxidative damage to TE has been implicated in vascular diseases, but the isoform-specific effects remain poorly understood ...
Karoline Lindgaard Mikkelsen +3 more
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Pathological investigations and correlation research of microfibrillar-associated protein 4 and tropoelastin in oral submucous fibrosis [PDF]
BMC Oral Health, 2021 Background Oral submucous fibrosis (OSF), distinguished by abnormal collagen deposition, is a potentially malignant disorder with 4.2% (95% CI 2.7–5.6%) of malignant transformation and rising global prevalence.
Binjie Liu, Wenqun Gou, Hui Feng
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Development of tropoelastin-functionalized anisotropic PCL scaffolds for musculoskeletal tissue engineering [PDF]
Regenerative Biomaterials, 2022 The highly organized extracellular matrix (ECM) of musculoskeletal tissues, encompassing tendons, ligaments and muscles, is structurally anisotropic, hierarchical and multi-compartmental.
Miao Zhang +6 more
openalex +2 more sources
Journal of Functional Biomaterials, 2023 Mesenchymal stem cells (MSCs) have recently been widely used to treat osteoarthritis (OA). Our prior research shows that tropoelastin (TE) increases MSC activity and protects knee cartilage from OA-related degradation.
Shuo Meng +8 more
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