Results 21 to 30 of about 7,380 (205)

Electrochemical and theoretical evaluation of the interaction between dna and amodiaquine: evidence of the guanine adduct formation

Química Nova, 2010
The electrochemical behavior of the interaction of amodiaquine with DNA on a carbon paste electrode was studied using voltametric techniques. In an acid medium, an electroactive adduct is formed when amodiaquine interacts with DNA.
Maria Lara P. M. Arguelho, José do Patrocínio H. Alves, Nelson R. Stradiotto, Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz   +5 more
doaj   +1 more source

Is amodiaquine failing in Rwanda? Efficacy of amodiaquine alone and combined with artesunate in children with uncomplicated malaria [PDF]

Tropical Medicine & International Health, 2004
SummaryWe investigated the safety and efficacy of amodiaquine alone (AQ) and combined with artesunate (AQ + AS) in 308 Rwandan children 6–59 months old with uncomplicated Plasmodium falciparum malaria attending three sentinel sites. The two treatment regimes were well tolerated and no serious adverse events were recorded. After excluding new infections,
Rwagacondo, C. E., Karema, C., Mugisha, V., Erhart, A., Dujardin, J. C., Van Overmeir, C., Ringwald, P., D'Alessandro, U.   +7 more
openaire   +5 more sources

Artemisinin-based combination therapy for uncomplicated Plasmodium falciparum malaria in Colombia

Malaria Journal, 2007
Background Artemisinin-based combination therapy (ACT) is being widely promoted as a strategy to counteract the increase in Plasmodium falciparum antimalarial drug resistance.
Taylor Walter RJ, Olliaro Piero, Gonzalez Iveth, Osorio Lyda   +3 more
doaj   +1 more source

Field-adapted sampling of whole blood to determine the levels of amodiaquine and its metabolite in children with uncomplicated malaria treated with amodiaquine plus artesunate combination

Malaria Journal, 2009
Background Artemisinin combination therapy (ACT) has been widely adopted as first-line treatment for uncomplicated falciparum malaria. In Uganda, amodiaquine plus artesunate (AQ+AS), is the alternative first-line regimen to Coartem® (artemether ...
Gustafsson Lars L, Mahindi Margarita, Mukonzo Jackson, Obua Celestino, Ntale Muhammad, Beck Olof, Ogwal-Okeng Jasper W   +6 more
doaj   +1 more source

Amodiaquine-induced Agranulocytosis: Toxic Effect of Amodiaquine in Bone Marrow Cultures In Vitro [PDF]

BMJ, 1973
A case of agranulocytosis is reported in which amodiaquine, to which the patient had been exposed, was found to be toxic to the patient's bone marrow cells when these were cultured in an agar colony system in vitro. This technique should be investigated in other patients with agranulocytosis as a possible means of detecting toxic agents.
Levi Ja, P. C. Vincent, D. E. Lind
openaire   +3 more sources

Interactions between DNA purinic bases and amodiaquine: A theoretical approach

Orbital: The Electronic Journal of Chemistry, 2010
We study theoretically the amodiaquine-adenine and amodiaquine-guanine adducts formation using Density Functional Theory (B3LYP) and the 6-31G(d) basis set for the geometry optimizations and 6-31+G(d,p) for the analysis of the global indexes ...
Valdemar Lacerda Júnior, José Maria Pires, Adilson Beatriz, Maria Lara Palmeira de Macedo Arguelho   +3 more
doaj   +1 more source

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

Frontiers in Pharmacology, 2018
Formation of the reactive amodiaquine quinoneimine (AQ-QI) and N-desethylamodiaquine quinoneimine (DEAQ-QI) plays an important role in the toxicity of the anti-malaria drug amodiaquine (AQ).
Yongjie Zhang, Yongjie Zhang, Shalenie P. den Braver-Sewradj, Michiel W. den Braver, Steven Hiemstra, Nico P. E. Vermeulen, Bob van de Water, Jan N. M. Commandeur, J. C. Vos   +8 more
doaj   +1 more source

INTRAVENOUS AMODIAQUINE AND ORAL AMODIAQUINE/ERYTHROMYCIN IN THE TREATMENT OF CHLOROQUINE-RESISTANT FALCIPARUM MALARIA

The Lancet, 1985
In eastern Thailand, 14 adults with moderately severe falciparum malaria were treated with intravenous amodiaquine dihydrochloride, loading dose 10 mg base/kg infused over 4 h followed by three further intravenous infusions of 5 mg base/kg at 24, 48, and 72 h.
Looareesuwan, S, Phillips, R, White, N, Karbwang, J, Benjasurat, Y, Attanath, P, Warrell, D   +6 more
openaire   +4 more sources

Comparative efficacy of artesunate and sulphadoxine-pyrimethamine combination with artesunate and amodiaquine combination in uncomplicated falciparum malaria in children

Paediatrica Indonesiana, 2008
Background Malaria is still an important cause of mortality and morbidity in children and adults in tropical countries. Multidrug resistance againts chloroquine and sulphadox- ine-pyrimethamine had brought to an introduction of artemisinin-based ...
Jose Meky Mandei, Novie Homenta Rampengan, Suryadi Nicolaas, Napoleon Tatura, Ari Lukas Runtunuwu, Tony Homenta Rampengan   +5 more
doaj   +1 more source

Amodiaquine and Hepatitis

Annals of Internal Medicine, 1986
Excerpt To the editor: Prophylaxis of malaria by amodiaquine is dangerous (1, 2). At least 20 cases of amodiaquine-associated agranulocytosis have been discovered so far in Switzerland, and 12 of t...
openaire   +3 more sources