Results 21 to 30 of about 70,987 (250)
Haploidentical HSCT for hemoglobinopathies: improved outcomes with TCRαβ+/CD19+-depleted grafts
Blood Advances, 2018 : We examined outcomes of haploidentical hematopoietic cell transplantation (haplo-HCT) using T-cell receptor αβ+ (TCRαβ+)/CD19+-depleted grafts (TCR group, 14 patients) in children with hemoglobinopathies.
Javid Gaziev +11 more
doaj +1 more source
Pulmonary Circulation, 2021 Sickle cell anemia and β‐thalassemia intermedia are very different genetically determined hemoglobinopathies predisposing to pulmonary hypertension. The etiologies responsible for the associated development of pulmonary hypertension in both diseases are ...
Paul W. Buehler +8 more
doaj +1 more source
The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment
Trends in Peptide and Protein Sciences, 2021 Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
doaj +1 more source
Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. [PDF]
, 2018 OBJECTIVE: To determine the mortality rate of children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil. METHODS: The number of deaths, the mortality rate and the causes of deaths in patients with sickle cell anemia who were ...
Ballas, Samir K. +5 more
core +3 more sources
Acute Exercise Challenge and Airway Dynamics in Youth With Sickle Cell Anemia: A Multicenter Study. [PDF]
Am J HematolChanges in airway dynamics in children with sickle cell anemia after maximal cardiopulmonary exercise testing and a controlled intensity interval excercise challenge. ABSTRACT Sickle cell anemia (SCA) leads to reduced physical functioning and cardiopulmonary fitness. Prior studies suggest that airway hyperresponsiveness to bronchoprovocation testing is
Cohen RT +9 more
europepmc +2 more sources
Comorbidities in aging patients with sickle cell disease. [PDF]
, 2018 Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
core +2 more sources
Haematologica, 2013 The aim of the study was to determine the factors associated with resting and exercise-induced hemoglobin oxygen desaturation. The well-established six-minute walk test was conducted in 107 sickle cell children (50 with sickle hemoglobin C disease and 57
Xavier Waltz +12 more
doaj +1 more source
Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania
Haematologica, 2011 Background Reduced growth is common in children with sickle cell anemia, but few data exist on associations with long-term clinical course. Our objective was to determine the prevalence of malnutrition at enrolment into a hospital-based cohort and ...
Sharon E. Cox +8 more
doaj +1 more source
JAMA: The Journal of the American Medical Association, 1922 Recent medical literature contains the records of three patients, all negroes, or negroes with an admixture of Caucasian blood, in whom severe anemia, characterized by certain peculiar morphologic alterations of the red blood cells, was present. The first case was reported by Herrick.1Washburn2published the records of a patient whose blood showed ...
openaire +1 more source
BMC Research Notes, 2018 Objective By measuring the associations between the presence of sickle cell and β-thalassemia genes, we assessed the extent to which these hemoglobinopathies contribute to the high prevalence of anemia observed in preschool-aged children and women of ...
James P. Wirth +4 more
doaj +1 more source