Results 21 to 30 of about 634,895 (315)
Biochemical Stability and Microbial Control of Reconstituted DaxibotulinumtoxinA-lanm for Injection
Toxins, 2023 DaxibotulinumtoxinA-lanm for injection (DAXI) is a unique US Food and Drug Administration-approved product comprising daxibotulinumtoxinA and a stabilizing excipient peptide (RTP004).
Kimberlee Ellis +2 more
doaj +1 more source
Molecules, 2022 In past decades, anticancer research has led to remarkable results despite many of the approved drugs still being characterized by high systemic toxicity mainly due to the lack of tumor selectivity and present pharmacokinetic drawbacks, including low ...
Giuseppina Ioele +6 more
doaj +1 more source
Nanocrystals of Poorly Soluble Drugs: Drug Bioavailability and Physicochemical Stability [PDF]
Pharmaceutics, 2018 Many approaches have been developed over time to counter the bioavailability limitations of poorly soluble drugs. With advances in nanotechnology in recent decades, science and industry have been approaching this issue through the formulation of drugs as nanocrystals, which consist of pure drugs and a minimum of surface active agents required for ...
Maria Rosa Gigliobianco +3 more
openaire +7 more sources
Stability investigation of total parenteral nutrition admixture prepared in a hospital pharmacy [PDF]
Vojnosanitetski Pregled, 2008 Background/Aim. In the cases when nutrition of patients can not be orally nor enterally performed, parenteral nutrition is a method of the therapy that provides more successful and rapid recovery. In that way, hospitalization can be significantly shorter,
Mirković Dušica +3 more
doaj +1 more source
Machine Learning Predicts Drug Metabolism and Bioaccumulation by Intestinal Microbiota
Pharmaceutics, 2021 Over 150 drugs are currently recognised as being susceptible to metabolism or bioaccumulation (together described as depletion) by gastrointestinal microorganisms; however, the true number is likely higher.
Laura E. McCoubrey +5 more
doaj +1 more source
Crystals, 2023 Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj +1 more source
Design Of Drug-Like Protein-Protein Interaction Stabilizers Guided By Chelation-Controlled Bioactive Conformation Stabilization [PDF]
Chemistry - A European Journal, Wiley-VCH Verlag, 2020, 26 (31),
pp.7131-7139, 2020 The protein-protein interactions (PPIs) of 14-3-3 proteins are a model system for studying PPI stabilization. The complex natural product Fusicoccin A stabilizes many 14-3-3 PPIs but is not amenable for use in SAR studies, motivating the search for more drug-like chemical matter.
arxiv +1 more source
Stability of peptide drugs in the colon
European Journal of Pharmaceutical Sciences, 2015 This study was the first to investigate the colonic stability of 17 peptide molecules (insulin, calcitonin, glucagon, secretin, somatostatin, desmopressin, oxytocin, Arg-vasopressin, octreotide, ciclosporin, leuprolide, nafarelin, buserelin, histrelin, [D-Ser(4)]-gonadorelin, deslorelin, and goserelin) in a model of the large intestine using mixed ...
Abdul Basit +4 more
openaire +3 more sources
Understanding Enhanced Mechanical Stability of DNA in the Presence of Intercalated Anticancer Drug: Implications for DNA Associated Processes [PDF]
J. Chem. Phys. 151, 164902 (2019), 2019 Most of the anticancer drugs bind to double-stranded DNA (dsDNA) by intercalative-binding mode. Although experimental studies have become available recently, a molecular-level understanding of the interactions between the drug and dsDNA that lead to the stability of the intercalated drug is lacking.
arxiv +1 more source
EVALUATION OF THE STABILITY OF VIGABATRIN IN HOSPITALAR EXTEMPORANEOUS FORMULATIONS
Drug Analytical Research, 2019 The aim of this study was to analyze the chemical stability of the anticonvulsant vigabatrin extemporaneous formulation from tablets in storage conditions of different temperatures and types of packaging used.
Marcio Vinicius Ayres +4 more
doaj +1 more source