Results 21 to 30 of about 391,284 (388)

Transgenic solutions for the germline [PDF]

WormBook, 2010
One of the most thrilling experiments in biology is to introduce a gene of one’s own design into a favorite animal and examine the effect in the transgenic progeny. Methods to construct, transform and monitor transgenes have been available to worm breeders since the pioneering work of Andy Fire and Craig Mello (Fire, 1986; Mello and Fire, 1995) and the
Geraldine Seydoux, Christopher Merritt
openaire   +3 more sources

Germline Stem Cells [PDF]

Cold Spring Harbor Perspectives in Biology, 2011
Sperm and egg production requires a robust stem cell system that balances self-renewal with differentiation. Self-renewal at the expense of differentiation can cause tumorigenesis, whereas differentiation at the expense of self-renewal can cause germ cell depletion and infertility.
Spradling, Allan, Fuller, Margaret T, Braun, Robert E, Yoshida, Shosei   +3 more
openaire   +2 more sources

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

New England Journal of Medicine, 2017
n engl j med 377;6 nejm.org August 10, 2017 523 From the Memorial Sloan Kettering Cancer Center, New York (M.R.); Seoul National University Hospital, Cancer Research Institute, Seoul National University College of Medicine, Seoul, South Korea (S.-A.I ...
M. Robson, S. Im, E. Senkus, Bing-he Xu, S. Domchek, N. Masuda, S. Delaloge, Wei Li, N. Tung, A. Armstrong, Wenting Wu, C. Goessl, S. Runswick, P. Conte   +13 more
semanticscholar   +2 more sources

Germline‐targeting immunogens [PDF]

Immunological Reviews, 2017
SummaryIn 2009, Dimitrov's group reported that the inferred germline (iGL) forms of several HIV‐1 broadly neutralizing antibodies (bNAbs) did not display measurable binding to a recombinant gp140 Env protein (derived from the dual‐tropic 89.6 virus), which was efficiently recognized by the mature (somatically mutated) antibodies.
Marie Pancera, Andrew T. McGuire, Leonidas Stamatatos, Leonidas Stamatatos   +3 more
openaire   +3 more sources

Antagonism between germ cell-less and Torso receptor regulates transcriptional quiescence underlying germline/soma distinction

eLife, 2021
Transcriptional quiescence, an evolutionarily conserved trait, distinguishes the embryonic primordial germ cells (PGCs) from their somatic neighbors. In Drosophila melanogaster, PGCs from embryos maternally compromised for germ cell-less (gcl) misexpress
Megan M Colonnetta, Lauren R Lym, Lillian Wilkins, Gretchen Kappes, Elias A Castro, Pearl V Ryder, Paul Schedl, Dorothy A Lerit, Girish Deshpande   +8 more
doaj   +1 more source

Imaging plant germline differentiation within Arabidopsis flowers by light sheet microscopy [PDF]

, 2020
In higher plants, germline differentiation occurs during a relatively short period within developing flowers. Understanding of the mechanisms that govern germline differentiation lags behind other plant developmental processes.
Bainar, Petr, Heckmann, Stefan, Klímová, Jana, Krumnikl, Michal, Mikulková, Pavlína, Pečinková, Jana, Tomančák, Pavel, Valuchová, Soňa, Říha, Karel   +8 more
core   +1 more source

A robust benchmark for detection of germline large deletions and insertions

Nature Biotechnology, 2020
New technologies and analysis methods are enabling genomic structural variants (SVs) to be detected with ever-increasing accuracy, resolution and comprehensiveness. To help translate these methods to routine research and clinical practice, we developed a
J. Zook, Nancy F. Hansen, Nathan D. Olson, Lesley M. Chapman, J. Mullikin, Chunlin Xiao, S. Sherry, S. Koren, A. Phillippy, P. Boutros, S. M. Sahraeian, Vincent Huang, A. Rouette, Noah Alexander, C. Mason, I. Hajirasouliha, Camir Ricketts, Joyce Lee, R. Tearle, Ian T. Fiddes, Á. M. Barrio, J. Wala, Andrew Carroll, Noushin Ghaffari, O. Rodriguez, A. Bashir, S. Jackman, J. Farrell, A. Wenger, C. Alkan, Arda Soylev, M. Schatz, S. Garg, George M. Church, T. Marschall, Ken Chen, Xian Fan, A. English, J. Rosenfeld, Weichen Zhou, Ryan E. Mills, Jay M. Sage, Jennifer R. Davis, Michael D. Kaiser, J. Oliver, Anthony P. Catalano, Mark J. P. Chaisson, Noah Spies, F. Sedlazeck, M. Salit   +49 more
semanticscholar   +1 more source

Segment number threshold determines juvenile onset of germline cluster expansion in Platynereis dumerilii

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 2021
Development of sexual characters and generation of gametes are tightly coupled with growth. Platynereis dumerilii is a marine annelid that has been used to study germline development and gametogenesis. P. dumerilii has germ cell clusters found across the
Emily Kuehn, David S. Clausen, Ryan W. Null, Bria Metzger, A. Willis, B. Özpolat   +5 more
semanticscholar   +1 more source

A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report

Frontiers in Oncology, 2022
Central nervous system germ cell tumors (CNS GCTs) are a heterogeneous group of primary CNS tumors. GCTs are more common and mostly observed in pediatric and young adult patients.
Xizan Yue, Bo Liu, Tiantian Han, Tiantian Han, Tiantian Han, Ningning Luo, Ningning Luo, Ningning Luo, Guanghua Lu, Guanghua Lu, Guanghua Lu, Didi Guo, Didi Guo, Didi Guo, Fanfeng Bu, Fanfeng Bu, Fanfeng Bu, Guangyu Wang   +17 more
doaj   +1 more source

Androgen promotes differentiation of PLZF+ spermatogonia pool via indirect regulatory pattern

Cell Communication and Signaling, 2019
Background Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR).
Jingjing Wang, Jinmei Li, Wei Xu, Qin Xia, Yunzhao Gu, Weixiang Song, Xiaoyu Zhang, Yang Yang, Wei Wang, Hua Li, Kang Zou   +10 more
doaj   +1 more source