Results 21 to 30 of about 509,115 (292)

Short-term effect of growth hormone treatment in childhood leukemia survivors with growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2022
Purpose Survivors of childhood leukemia are at risk of growth impairment due to intensive chemotherapy and radiation treatments. This study investigated the auxological and biochemical characteristics of childhood leukemia survivors diagnosed with growth
Chungwoo Shin, Min Jeong Jang, Seongkoo Kim, Jae Wook Lee, Nack-Gyun Chung, Bin Cho, Min Ho Jung, Byung-Kyu Suh, Moon Bae Ahn   +8 more
doaj   +1 more source

Effect of growth hormone therapy on Taiwanese children with growth hormone deficiency

Journal of the Formosan Medical Association, 2012
Human growth hormone (GH) has been successfully used in children with GH deficiency (GHD). However, there are few published data on the effect of GH in Taiwanese children with GHD.
Ying-Hua Huang, Yau-Yau Wai, Yang-Hau Van, Fu-Sung Lo   +3 more
doaj   +1 more source

Growth hormone and Klotho [PDF]

Journal of Endocrinology, 2013
Acromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. TheKlothogene was identified in mice following its accidental disruption by ectopic DNA.
Schmid, Christoph, Neidert, Marian C, Tschopp, Oliver, Sze, Lisa, Bernays, René L   +4 more
openaire   +2 more sources

Adult growth hormone deficiency

Indian Journal of Endocrinology and Metabolism, 2011
Adult growth hormone deficiency (AGHD) is being recognized increasingly and has been thought to be associated with premature mortality. Pituitary tumors are the commonest cause for AGHD.
Vishal Gupta
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Parameters Used for Evaluation of the Response to Treatment with Recombinant Human Growth Hormone in Paediatric and Adult Populations in Poland: Review

Journal of Education, Health and Sport
Introduction and purpose  Recombinant human growth hormone (rhGH) therapy has been the standard treatment  for paediatric short stature for many years, and a therapeutic option for the replacement therapy of growth hormone deficiency in the post ...
Agata Kotkowiak, Mikołaj Łabuda, Agnieszka Szema , Jakub Sikora, Karolina Knychalska, Klaudia Królikowska, Aleksandra Słojewska, Teresa Sowińska, Oliwia Mentel, Adrianna Bogucka   +9 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

Growth hormone response to growth hormone-releasing peptide-2 in growth hormone-deficient Little mice

Clinics, 2012
OBJECTIVE: To investigate a possible direct, growth hormone-releasing, hormone-independent action of a growth hormone secretagogue, GHRP-2, in pituitary somatotroph cells in the presence of inactive growth hormonereleasing hormone receptors.
Cibele N. Peroni, Cesar Y. Hayashida, Nancy Nascimento, Viviane C. Longuini, Rodrigo A. Toledo, Paolo Bartolini, Cyril Y. Bowers, Sergio P.A. Toledo   +7 more
doaj   +1 more source

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

Molecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park, Jae Won Oh, Hyewon Chung, Jung Won Kwon, Yi Rang Na, Kwang Pyo Kim, Seung Hyeok Seok   +6 more
wiley   +1 more source

Efficacy of growth hormone therapy in adults with childhood-onset growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2014
PurposeGrowth hormone (GH) plays a key role in the regulation of body composition, lipid metabolism, and quality of life in adults with GH deficiency (GHD).
Ja Hye Kim, Ja Hyang Cho, Han-Wook Yoo, Jin-Ho Choi   +3 more
doaj   +1 more source