Results 21 to 30 of about 115,102 (75)

The potential roles of type I interferon activated neutrophils and neutrophil extracellular traps (NETs) in the pathogenesis of primary Sjögren’s syndrome

Arthritis Research & Therapy, 2022
Objective Neutrophils and aberrant NETosis have been implicated in the pathogenesis of diverse autoimmune diseases; however, their roles in primary Sjögren’s syndrome (pSS) remain unclear.
Yu Peng, Xunyao Wu, Shulan Zhang, Chuiwen Deng, Lidan Zhao, Mu Wang, Qingjun Wu, Huaxia Yang, Jiaxin Zhou, Linyi Peng, Xuan Luo, Yingying Chen, Anqi Wang, Qiufeng Xiao, Wen Zhang, Yan Zhao, Xiaofeng Zeng, Yunyun Fei   +17 more
doaj   +1 more source

Agent-Based Modeling of Host-Pathogen Systems: The Successes and Challenges [PDF]

Information Sciences, Volume 179, Issue 10, 29 April 2009, Pages 1379-1389, 2008
Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immunology and disease pathology. We review various agent-based models relevant to host-pathogen systems and discuss their contributions to our understanding of biological ...
arxiv   +1 more source

RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Cell Reports, 2016
Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic.
Gerd Meyer zu Horste, Chuan Wu, Chao Wang, Le Cong, Mathias Pawlak, Youjin Lee, Wassim Elyaman, Sheng Xiao, Aviv Regev, Vijay K. Kuchroo   +9 more
doaj   +1 more source

Augmenting adaptive immunity: progress and challenges in the quantitative engineering and analysis of adaptive immune receptor repertoires [PDF]

Mol. Syst. Des. Eng. (2019), 2019
The adaptive immune system is a natural diagnostic and therapeutic. It recognizes threats earlier than clinical symptoms manifest and neutralizes antigen with exquisite specificity. Recognition specificity and broad reactivity is enabled via adaptive B- and T-cell receptors: the immune receptor repertoire.
arxiv   +1 more source

Uveitis and hypereosinophilia associated with dupilumab in an atopic dermatitis patient

Journal of Dermatological Treatment, 2023
Uveitis is a rare adverse event of dupilumab, that typically affects both eyes and often leads to discontinuation of therapy. In this article, we report a case of a 28-year-old female with atopic dermatitis who developed new-onset iridocyclitis, a form ...
Shiyu Zhang, Lu Lu, Jindi Feng, Zhonghui Hu, Hongbin Song, Lu Yang, Yuehua Liu, Di Chen, Tao Wang   +8 more
doaj   +1 more source

Is Coronavirus-Related Research Becoming More Interdisciplinary? A Perspective of Co-occurrence Analysis and Diversity Measure of Scientific Articles [PDF]

, 2021
The outbreak of coronavirus disease 2019 (COVID-19) has had a significant repercussion on the health, economy, politics and environment, making coronavirus-related issues more complicated and difficult to solve adequately by relying on a single field. Interdisciplinary research can provide an effective solution to complex issues in the related field of
arxiv   +1 more source

Peripheral B-Cell Immunophenotyping Identifies Heterogeneity in IgG4-Related Disease

Frontiers in Immunology, 2021
ObjectivesTo elucidate heterogeneity of IgG4-related disease (IgG4-RD) based on B cell immunophenotyping.MethodsImmunophenotyping of 4 B-cell subsets in peripheral blood from patients with active IgG4-RD (aIgG4-RD, n=105) was performed using flow ...
Jieqiong Li, Zheng Liu, Panpan Zhang, Wei Lin, Hui Lu, Yu Peng, Linyi Peng, Jiaxin Zhou, Mu Wang, Hua Chen, Lidan Zhao, Li Wang, Chenman Qin, Chaojun Hu, Xiaofeng Zeng, Yan Zhao, Yunyun Fei, Wen Zhang   +17 more
doaj   +1 more source

Alterations of the human gut microbiome in multiple sclerosis

Nature Communications, 2016
The gut microbiome has been implicated in several autoimmune disorders. Here, the authors study the gut microbiome of patients with multiple sclerosis, and find correlations between altered abundance of certain gut microorganisms and changes in ...
Sushrut Jangi, Roopali Gandhi, Laura M. Cox, Ning Li, Felipe von Glehn, Raymond Yan, Bonny Patel, Maria Antonietta Mazzola, Shirong Liu, Bonnie L. Glanz, Sandra Cook, Stephanie Tankou, Fiona Stuart, Kirsy Melo, Parham Nejad, Kathleen Smith, Begüm D. Topçuolu, James Holden, Pia Kivisäkk, Tanuja Chitnis, Philip L. De Jager, Francisco J. Quintana, Georg K. Gerber, Lynn Bry, Howard L. Weiner   +24 more
doaj   +1 more source

Clinical Characteristics and Prognoses of Patients With Systemic Lupus Erythematosus Hospitalized for Pulmonary Infections

Frontiers in Medicine, 2021
Objective: To identify factors associated with mortality in SLE patients who were hospitalized for pulmonary infections (PIs).Methods: This single-center retrospective study analyzed the characteristics and risk factors for mortality in 95 SLE patients ...
Yanli Yang, Yanli Yang, Hui Jiang, Chuhan Wang, Nan Jiang, Chanyuan Wu, Shangzhu Zhang, Wei Jiang, Jinmin Peng, Li Weng, Jiuliang Zhao, Qian Wang, Mengtao Li, Bin Du, Yan Zhao, Xiaofeng Zeng   +15 more
doaj   +1 more source

Sensitivity analysis in an Immuno-Epidemiological Vector-Host Model [PDF]

arXiv, 2021
Sensitivity Analysis (SA) is a useful tool to measure the impact of changes in model parameters on the infection dynamics, particularly to quantify the expected efficacy of disease control strategies. SA has only been applied to epidemic models at the population level, ignoring the effect of within-host virus-with-immune-system interactions on the ...
arxiv