Results 21 to 30 of about 560,370 (324)
Clinical and Translational Allergy, 2014 AbstractPeanut allergy is common and can be a cause of severe, life‐threatening reactions. It is rarely outgrown like other food allergies, such as egg and milk. Peanut allergy has a significant effect on the quality of life of sufferers and their families, due to dietary and social restrictions, but mainly stemming from fear of accidental peanut ...
Katherine Anagnostou, Andrew Clark
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Modulation of Endosome Function, Vesicle Trafficking and Autophagy by Human Herpesviruses
Cells, 2021 Human herpesviruses are a ubiquitous family of viruses that infect individuals of all ages and are present at a high prevalence worldwide. Herpesviruses are responsible for a broad spectrum of diseases, ranging from skin and mucosal lesions to blindness ...
Eduardo I. Tognarelli +6 more
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Gut microbiome modulates response to anti–PD-1 immunotherapy in melanoma patients
Science, 2018 Good bacteria help fight cancer Resident gut bacteria can affect patient responses to cancer immunotherapy (see the Perspective by Jobin). Routy et al. show that antibiotic consumption is associated with poor response to immunotherapeutic PD-1 blockade ...
V. Gopalakrishnan +69 more
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NASH limits anti-tumour surveillance in immunotherapy-treated HCC
Nature, 2021 Hepatocellular carcinoma (HCC) can have viral or non-viral causes1–5. Non-alcoholic steatohepatitis (NASH) is an important driver of HCC. Immunotherapy has been approved for treating HCC, but biomarker-based stratification of patients for optimal ...
D. Pfister +109 more
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Cancers, 2011 Much of our knowledge regarding cancer immunotherapy has been derived from sarcoma models. However, translation of preclinical findings to bedside success has been limited in this disease, though several intriguing clinical studies hint at the potential efficacy of this treatment modality.
Gouw, Launce G +3 more
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Neoantigens in cancer immunotherapy
Science, 2015 The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to distinguish cancer cells from noncancer cells has long remained obscure.
T. Schumacher, R. Schreiber
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Cellular & Molecular Immunology, 2020 Immunotherapy has revolutionized cancer treatment and rejuvenated the field of tumor immunology. Several types of immunotherapy, including adoptive cell transfer (ACT) and immune checkpoint inhibitors (ICIs), have obtained durable clinical responses, but
Yuanyuan Zhang, Zemin Zhang
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Nature Communications, 2022 Plasma B cells (PC) are a potential source for protein replacement as they could be engineered to secrete protein other than antibody. Here the authors engineer B cells to express exogenous proteins and demonstrate that these cells can persist long term ...
Rene Yu-Hong Cheng +11 more
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Immunotherapy for osteosarcoma [PDF]
Human Vaccines & Immunotherapeutics, 2020 Osteosarcoma (OS) is the most common malignant bone tumor and often occurs in children. Chemotherapy with methotrexate, cisplatin, doxorubicin, and ifosfamide has greatly improved the prognosis of patients with OS, and most patients have been able to preserve their limbs.
Yoshihiro Matsumoto, Kenichiro Yahiro
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Immunotherapy for thymoma [PDF]
Journal of Thoracic Disease, 2020 Thymic epithelial tumors (TETs) are rare thymic neoplasms. There are approximately 1.5 cases per million TETs per year. They are the most common anterior mediastinal tumors in adults. Due to limited activity of available treatment options novel strategies and treatment options are needed and treatment with immune checkpoint inhibitors is an attractive ...
Kristina Krpina +7 more
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