Results 21 to 30 of about 6,961,893 (372)
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Proceedings of the National Academy of Sciences of the United States of America, 1995 Normal somatic cells invariably enter a state of irreversibly arrested growth and altered function after a finite number of divisions. This process, termed replicative senescence, is thought to be a tumor-suppressive mechanism and an underlying cause of ...
Goberdhan P Dimri +9 more
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Dermatology Research and Practice, 2010 The structure, function, and regulation of desmosomal adhesion in vivo are discussed. Most desmosomes in tissues exhibit calcium‐independent adhesion, which is strongly adhesive or “hyperadhesive”. This is fundamental to tissue strength. Almost all studies in culture are done on weakly adhesive, calcium‐dependent desmosomes, although hyperadhesion can ...
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Frontiers in Psychiatry, 2021 While anosognosia is often present in Alzheimer's disease, the degree of awareness of cognitive difficulties in the earlier stages, such as Mild Cognitive Impairment (MCI), is less clear.
Christine Bastin +7 more
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eLife, 2022 Sleep alteration is a hallmark of ageing and emerges as a risk factor for Alzheimer’s disease (AD). While the fine-tuned coalescence of sleep microstructure elements may influence age-related cognitive trajectories, its association with AD processes is ...
Daphne Chylinski +13 more
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Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
Science, 2005 Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage.
A. Nimmerjahn, F. Kirchhoff, F. Helmchen
semanticscholar +1 more source
Frontiers in Aging Neuroscience, 2021 Studies exploring the simultaneous influence of several physiological and environmental factors on domain-specific cognition in late middle-age remain scarce.
Justinas Narbutas +22 more
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Trends in Microbiology, 2013 Bacteria can grow and proliferate either as single, independent cells or organized in aggregates commonly referred to as biofilms. When bacteria succeed in forming a biofilm within the human host, the infection often becomes very resistant to treatment and can develop into a chronic state.
Morten Alhede +12 more
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Dopamine Neuron Challenge Test for early detection of Parkinson’s disease
npj Parkinson's Disease, 2021 Diagnosing Parkinson’s disease (PD) before the clinical onset proves difficult because the hallmark PD symptoms do not manifest until more than 60% of dopamine neurons in the substantia nigra pars compacta have been lost.
Jingheng Zhou +4 more
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Plasma and cavitation dynamics during pulsed laser microsurgery in vivo [PDF]
Phys. Rev. Lett. 99, 158104 (2007), 2007 We compare the plasma and cavitation dynamics underlying pulsed laser microsurgery in water and in fruit fly embryos (in vivo) - specifically for nanosecond pulses at 355 and 532 nm. We find two key differences. First, the plasma-formation thresholds are lower in vivo - especially at 355 nm - due to the presence of endogenous chromophores that serve as
arxiv +1 more source
Molecules, 2021 Alterations in viscosity of biological fluids and tissues play an important role in health and diseases. It has been demonstrated that the electron paramagnetic resonance (EPR) spectrum of a 13C-labeled trityl spin probe (13C-dFT) is highly sensitive to ...
Murugesan Velayutham +4 more
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