Ultrasensitive Quantitation of Genomic Chimerism by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing of Copy Number Deletion Polymorphisms. [PDF]
J Mol Diagn, 2022 Wu D +7 more
europepmc +2 more sources
Highly multiplexed molecular inversion probe genotyping: over 10,000 targeted SNPs genotyped in a single tube assay. [PDF]
Genome Research, 2005 Large-scale genetic studies are highly dependent on efficient and scalable multiplex SNP assays. In this study, we report the development of Molecular Inversion Probe technology with four-color, single array detection, applied to large-scale genotyping ...
P. Hardenbol +28 more
semanticscholar +2 more sources
PathogenMIPer: a tool for the design of molecular inversion probes to detect multiple pathogens [PDF]
BMC Bioinformatics, 2006 Background Here we describe PathogenMIPer, a software program for designing molecular inversion probe (MIP) oligonucleotides for use in pathogen identification and detection.
Akhras Michael +4 more
doaj +2 more sources
Ultrasensitive detection of acute myeloid leukemia minimal residual disease using single molecule molecular inversion probes [PDF]
Haematologica, 2017 The identification of minimal residual disease is the primary diagnostic finding which predicts relapse in patients treated for acute myeloid leukemia. Ultrasensitive detection of minimal residual disease would enable better patient risk stratification ...
Adam Waalkes +4 more
doaj +2 more sources
Analysis of molecular inversion probe performance for allele copy number determination [PDF]
Genome Biology, 2007 We have developed a new protocol for using molecular inversion probes to accurately and specifically measure allele copy number. The new protocol provides for significant improvements, including the reduction of input DNA (from 2 μg) by more than 25-fold
Yuker Wang +12 more
semanticscholar +2 more sources
Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma. [PDF]
Cancer Research, 2006 Genomic instability is a major feature of neoplastic development in colorectal carcinoma and other cancers. Specific genomic instability events, such as deletions in chromosomes and other alterations in gene copy number, have potential utility as ...
Hanlee P. Ji +7 more
semanticscholar +2 more sources
A molecular inversion probe and sequencing-based microsatellite instability assay for high throughput cancer diagnostics and Lynch syndrome screening [PDF]
bioRxiv, 2018 Background Clinical guidelines recommend microsatellite instability (MSI) and BRAF V600E testing of all colorectal cancers (CRCs) to screen for Lynch syndrome (LS), a hereditary predisposition to cancer.
R. Gallon +14 more
semanticscholar +2 more sources
Chemical Communications, 2014 DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line.
L. Carrascosa +7 more
semanticscholar +3 more sources
Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe-Based Single-Nucleotide Polymorphism Array. [PDF]
Journal of Molecular Diagnostics, 2016 Rajesh R. Singh +13 more
semanticscholar +2 more sources
JCO Clinical Cancer Informatics, 2019 PURPOSE Clinical targeted sequencing panels are important for identifying actionable variants for patients with cancer; however, existing approaches do not provide transparent and rationally designed clinical panels to accommodate the rapidly growing ...
Erica K. Barnell +18 more
semanticscholar +2 more sources