Structural diversity of axonemes across mammalian motile cilia. [PDF]
NatureReproduction, development and homeostasis depend on motile cilia, whose rhythmic beating is powered by a microtubule-based molecular machine called the axoneme. Although an atomic model of the axoneme is available for the alga Chlamydomonas reinhardtii1,
Leung MR +9 more
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Motile and non‐motile cilia in human pathology: from function to phenotypes [PDF]
The Journal of Pathology, 2017 AbstractCiliopathies are inherited human disorders caused by both motile and non‐motile cilia dysfunction that form an important and rapidly expanding disease category. Ciliopathies are complex conditions to diagnose, being multisystem disorders characterized by extensive genetic heterogeneity and clinical variability with high levels of lethality ...
H. Mitchison, E. Valente
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Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia [PDF]
Communications BiologyMotile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized ciliary motility. The formation of motile cilia is dependent on precisely controlled sequential processes including the generation,
Moonsup Lee +8 more
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Cilia density and flow velocity affect alignment of motile cilia from brain cells.
J Exp Biol, 2020 In many organs, thousands of microscopic ‘motile cilia’ beat in a coordinated fashion generating fluid flow. Physiologically, these flows are important in both development and homeostasis of ciliated tissues.
Pellicciotta N +6 more
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Entrainment of mammalian motile cilia in the brain with hydrodynamic forces. [PDF]
Proc Natl Acad Sci U S A, 2020 Significance We determine, in multiciliated mammalian cells, conditions for oscillatory flow to entrain brain motile cilia: Hydrodynamic forces of magnitude comparable to those generated by cilia themselves are sufficient to establish coordinated ...
Pellicciotta N +6 more
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Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia. [PDF]
PLoS Genetics, 2020 Motile cilia/flagella are essential for swimming and generating extracellular fluid flow in eukaryotes. Motile cilia harbor a 9+2 arrangement consisting of nine doublet microtubules with dynein arms at the periphery and a pair of singlet microtubules at ...
Hiroshi Yoke +7 more
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Computational Modeling of Motile Cilia-Driven Cerebrospinal Flow in the Brain Ventricles of Zebrafish Embryo [PDF]
Bioengineering, 2022 Motile cilia are hair-like microscopic structures which generate directional flow to provide fluid transport in various biological processes. Ciliary beating is one of the sources of cerebrospinal flow (CSF) in brain ventricles.
Huseyin Enes Salman +2 more
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SARS-CoV-2 replication in airway epithelia requires motile cilia and microvillar reprogramming. [PDF]
Cell, 2023 Wu CT +21 more
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LRRC6 regulates biogenesis of motile cilia by aiding FOXJ1 translocation into the nucleus. [PDF]
Cell Commun Signal, 2023 Background LRRC6 is an assembly factor for dynein arms in the cytoplasm of motile ciliated cells, and when mutated, dynein arm components remained in the cytoplasm.
Kim DY +8 more
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Motile Cilia: Innovation and Insight From Ciliate Model Organisms [PDF]
Frontiers in Cell and Developmental Biology, 2019 Ciliates are a powerful model organism for the study of basal bodies and motile cilia. These single-celled protists contain hundreds of cilia organized in an array making them an ideal system for both light and electron microscopy studies.
Brian A. Bayless +2 more
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