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Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
Molecules, 2016 Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda +2 more
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Frontiers in Microbiology, 2021 Neuraminidases (NAs) of H9N2 avian influenza virus (AIV) and H3N2 human seasonal influenza virus (HSIV) share similar antigenic structures. However, there are few reports on epitopes shared by these two NAs.
Fei Wang +25 more
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Multidrug-Resistant Pandemic (H1N1) 2009 Infection in Immunocompetent Child
Emerging Infectious Diseases, 2011 Recent case reports describe multidrug-resistant influenza A pandemic (H1N1) 2009 virus infection in immunocompromised patients exposed to neuraminidase inhibitors because of an I223R neuraminidase mutation.
Alireza Eshaghi +10 more
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Inherent Serum Inhibition of Influenza Virus Neuraminidases
Frontiers in Veterinary Science, 2021 Influenza virus vaccines have been designed for human and veterinary medicine. The development for broadly protective influenza virus vaccines has propelled the vaccine field to investigate and include neuraminidase (NA) components into new vaccine ...
Amanda L. Skarlupka +2 more
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Antivirals Targeting the Neuraminidase [PDF]
Cold Spring Harbor Perspectives in Medicine, 2020 The neuraminidase (NA) of influenza A and B viruses plays a distinct role in viral replication and has a highly conserved catalytic site. Numerous sialic (neuraminic) acid analogs that competitively bind to the NA active site and potently inhibit enzyme activity have been synthesized and tested.
Larisa V. Gubareva, Teena Mohan
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Molecules, 2016 Objective: To screen for influenza virus neuraminidase inhibition and to provide a reference for the clinical treatment of influenza using traditional Chinese medicines (TCM).
Xian-Ying Yang +4 more
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R292K Substitution and Drug Susceptibility of Influenza A(H7N9) Viruses
Emerging Infectious Diseases, 2013 Neuraminidase inhibitors are the only licensed antiviral medications available to treat avian influenza A(H7N9) virus infections in humans. According to a neuraminidase inhibition assay, an R292K substitution reduced antiviral efficacy of inhibitors ...
Katrina Sleeman +5 more
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Influenza and Other Respiratory Viruses, 2011 Please cite this paper as: Air. (2012) Influenza neuraminidase. Influenza and Other Respiratory Viruses 6(4), 245–256.Influenza neuraminidase is the target of two licensed antivirals that have been very successful, with several more in development. However, neuraminidase has been largely ignored as a vaccine target despite evidence that inclusion of ...
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Neuraminidase Production by Clostridia [PDF]
Journal of Medical Microbiology, 1978 The production of neuraminidase (EC 3.2.1.18) by a range of clostridial species was investigated with techniques previously developed to distinguish neuraminidase-negative and neuraminidase-positive strains of Clostridium perfringens (welchii). Large amounts of extracellular neuraminidase were produced by representative strains of C. perfringens and C.
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Cell Reports, 2023 Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging.
De-Jian Liu +13 more
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