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Thermodynamics of force-dependent folding and unfolding of small protein and nucleic acid structures [PDF]
Integrative Biology, 2015 In this paper, we outline the theoretical framework for understanding the equilibrium force-dependent folding and unfolding transitions of protein domains and small nucleic acid structures, both having small rigid folded structures and highly flexible ...
Mingxi Yao, Hu Chen, Jie Yan
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What Controls the Hybridization Thermodynamics of Spherical Nucleic Acids?
Journal of the American Chemical Society, 2015 The hybridization of free oligonucleotides to densely packed, oriented arrays of DNA modifying the surfaces of spherical nucleic acid (SNA)-gold nanoparticle conjugates occurs with negative cooperativity; i.e., each binding event destabilizes subsequent ...
Pratik S. Randeria +6 more
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Thermodynamics of Nucleic Acid Structural Modifications for Biotechnology Applications
, 2011 The repertoire of chemistry available to native nucleotides in DNA and RNA is limited to the purine and pyrimidine functional groups, along with the special role of the 2’-hydroxyl of RNA. The nucleobases have exocyclic amino groups and imines, neither of which is highly reactive or a good candidate for catalytic function.
Stefan Franzen
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, 2016 In the 1950’s, the research findings of James Watson, Francis Crick, Rosalind Franklin, and Maurice Wilkins led to the discovery of the deoxyribonucleic acid (DNA) double-helix conformation [1,2].
Fidelis Manyanga
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Theoretical Modeling of the Redox Thermodynamics of Nucleic Acid Building Blocks in the Condensed Phase. [PDF]
J Phys Chem BOlivieri A, Nardi AN, D'Abramo M.
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Molecular modeling and thermodynamics simulation of nucleic acids
, 2016 Nucleic acids participate in many cellular processes. DNA is responsible for gene heredity and its structure is mainly in double helix, whereas RNA has wide functions in gene transcription and regulation so its structures are varied among species.
You Xu
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The Effect of Magnesium on the Thermodynamics of Nucleic Acid Tertiary Contact Formation [PDF]
, 2014 Herschel M. Watkins +4 more
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Proceedings of the National Academy of Sciences of the United States of America, 1999 Tigran V. Chalikian +3 more
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Thermodynamic analysis of Zα domain-nucleic acid interactions [PDF]
Biochemical Journal, 2022 AbstractDNA/RNA molecules adopting the left-handed conformation (Z-form) have been attributed with immunogenic properties. However, their biological role and importance has been a topic of debate for many years. The discovery of Z-DNA/RNA binding domains (Zα domains) in varied proteins that are involved in the innate immune response, such as the ...
Bharath Srinivasan +2 more
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