Results 21 to 30 of about 2,374,258 (245)
Molecular and cellular pathogenesis of adamantinomatous craniopharyngioma. [PDF]
, 2015 Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients.
Martinez-Barbera, JP
core +1 more source
V-ATPase V0a1 promotes Weibel–Palade body biogenesis through the regulation of membrane fission
eLife, 2021 Membrane fission, the division of a membrane-bound structure into two discrete compartments, is essential for diverse cellular events, such as endocytosis and vesicle/granule biogenesis; however, the process remains unclear.
Yasuo Yamazaki, Yuka Eura, Koichi Kokame
doaj +1 more source
Non melanoma skin cancer pathogenesis overview [PDF]
, 2018 (1)Background: Non-melanoma skin cancer is the most frequently diagnosed cancer in humans. The process of skin carcinogenesis is still not fully understood.
Bottoni Ugo +3 more
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Nature Communications, 2017 Inflammasomes are protein complexes induced by pathogens for the secretion of pro-inflammatory cytokines IL-1β and IL-18 in immune cells. Here the authors show, using a new mouse model, that aberrant NLRC4 and ASC-dependent inflammasome activation in ...
Randilea D. Nichols +2 more
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Nature Communications, 2021 Understanding the mechanisms driving PI3K isoform dependency in prostate cancer can help the design of future clinical trials. Here, the authors show that gain-of-function mutations in PIK3CA or PIK3CB can confer PI3K p110 isoform dependency and that the
Ninghui Mao +17 more
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The Pathogenesis of Sepsis [PDF]
Annual Review of Pathology: Mechanisms of Disease, 2011 Sepsis is a serious clinical condition that represents a patient's response to a severe infection and has a very high mortality rate. Normal immune and physiologic responses eradicate pathogens, and the pathophysiology of sepsis is due to the inappropriate regulation of these normal reactions.
Catherine Valentine +4 more
openaire +2 more sources
Pathogenesis of chronic obstructive pulmonary disease [PDF]
, 2005 The current paradigm for the pathogenesis of chronic obstructive pulmonary disease is that chronic airflow limitation results from an abnormal inflammatory response to inhaled particles and gases in the lung. Airspace inflammation appears to be different
Macnee, W
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Control of CD4+ T cells to restrain inflammatory diseases via eukaryotic elongation factor 2 kinase
Signal Transduction and Targeted Therapy, 2023 CD4+ T cells, particularly IL-17-secreting helper CD4+ T cells, play a central role in the inflammatory processes underlying autoimmune disorders. Eukaryotic Elongation Factor 2 Kinase (eEF2K) is pivotal in CD8+ T cells and has important implications in ...
Hao-Yun Peng +9 more
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TSE pathogenesis in cattle and sheep [PDF]
, 2008 Many studies have been undertaken in rodents to study the pathogenesis of transmissible spongiform encephalopathies (TSE). Only a few studies have focused on the pathogenesis of bovine spongiform encephalopathy (BSE) and scrapie in their natural hosts ...
Bossers, A. +2 more
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Nature Communications, 2023 Three types of DNA methyl modifications have been detected in bacterial genomes, and mechanistic studies have demonstrated roles for DNA methylation in physiological functions ranging from phage defense to transcriptional control of virulence and host ...
Michael J. Tisza +6 more
doaj +1 more source