Results 21 to 30 of about 54,063 (260)

Electrospun nanofibers of polyCD/PMAA polymers and their potential application as drug delivery system [PDF]

Materials Science & Engineering C, v. 54, p. 252-261, 2015, 2015
Herein, we used an electrospinning process to develop highly efficacious and hydrophobic coaxial nanofibers based on poly-cyclodextrin (polyCD) associated with poly(methacrylic acid) (PMAA) that combines polymeric and supramolecular features for modulating the release of the hydrophilic drug, propranolol hydrochloride (PROP).
arxiv   +1 more source

Refractive Outcome in Preterm Newborns With ROP After Propranolol Treatment. A Retrospective Observational Cohort Study

Frontiers in Pediatrics, 2019
Background: Recent explorative studies suggest that propranolol reduces retinopathy of prematurity (ROP) progression, but the short-term effects of propranolol treatment at 1 year of corrected age have not been extensively evaluated.Methods: A multi ...
Luca Filippi, Giacomo Cavallaro, Lavinia Perciasepe, Elena Sandini, Gabriella Araimo, Giulia Regiroli, Giulia Regiroli, Genny Raffaeli, Paola Bagnoli, Massimo Dal Monte, Maura Calvani, Pina Fortunato, Silvia Osnaghi, Salvatore De Masi, Fabio Mosca, Fabio Mosca   +15 more
doaj   +1 more source

Same family, same mutation, different ECG

Molecular Genetics &Genomic Medicine, Volume 11, Issue 1, January 2023., 2023
This case shows ECG differences may also occur between family members who have the same gene mutation due to long QT syndrome. Abstract Background Different types of long QT syndromes (LQTS) have distinct ECG manifestations according to the type and magnitude of ion channel dysfunction.
Kürşat Akbuğa, Mustafa Karanfil
wiley   +1 more source

The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study.

PLoS ONE, 2019
BackgroundBeta-blockers can reduce recurrence, metastasis, and mortality in various cancers. In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular ...
Ping-Ying Chang, Chi-Hsiang Chung, Wei-Chou Chang, Chun-Shu Lin, Hsuan-Hwai Lin, Ming-Shen Dai, Ching-Liang Ho, Wu-Chien Chien   +7 more
doaj   +1 more source

Obesity treatment initiation, retention, and outcomes in the Veterans Affairs MOVE! Program among rural and urban veterans

Obesity Science &Practice, Volume 8, Issue 6, Page 784-793, December 2022., 2022
Abstract Objective Rural veterans have high obesity rates. Yet, little is known about this population's engagement with the Veterans Affairs (VA) weight management program (MOVE!). The study objective is to determine whether MOVE! enrollment, anti‐obesity medication use, bariatric surgery use, retention, and outcomes differ by rurality for veterans ...
Kathleen M. Robinson, Mark Vander Weg, Helena H. Laroche, Margaret Carrel, Jason Wachsmuth, Krista Kazembe, Mary Vaughan Sarrazin   +6 more
wiley   +1 more source

Inhibition of signaling downstream of beta‐2 adrenoceptor by propranolol in prostate cancer cells

The Prostate, Volume 83, Issue 3, Page 237-245, February 15, 2023., 2023
Abstract Background There is accumulating evidence that propranolol, an antagonist of beta‐1 and beta‐2 adrenoreceptors, extends survival of patients with prostate cancer; yet it is not known whether propranolol inhibits beta‐adrenergic signaling in prostate cancer cells, or systemic effects of propranolol play the leading role in slowing down cancer ...
Aljoharah Alaskar, Amaal Abdulraqeb Ali, Sazzad Hassan, Zakia Shinwari, Ayodele Alaiya, Urs von Holzen, Lance Miller, George Kulik   +7 more
wiley   +1 more source

Synthesis and Characterization of Photoswitchable Covalent Ligands for the β2‐Adrenoceptor

Angewandte Chemie, EarlyView.
A structure‐based design of a covalent photoswitchable ligand for the β2‐adrenergic receptor, a therapeutically relevant GPCR, is described. This tool facilitates the modification of the intrinsic activity of the protein by light. Computational analysis of its mechanism of action suggests that the photoswitch takes place within the binding pocket ...
Ulrike Wirth, Eduard Neu, Davide Provasi, Steffen Feustel, Maximilian F. Schmidt, Harald Hübner, Dorothée Weikert, Marta Filizola, Burkhard König, Peter Gmeiner   +9 more
wiley   +2 more sources

Fusion of the β2‐adrenergic receptor with either Gαs or βarrestin‐2 produces constitutive signaling by each pathway and induces gain‐of‐function in BEAS‐2B cells

FASEB BioAdvances, Volume 4, Issue 12, Page 758-774, December 2022., 2022
Abstract The β2AR is a prototypical G protein‐coupled receptor (GPCR) known to orchestrate different cellular responses by the stimulation of specific signaling pathways. The best‐established signaling pathways for the β2AR are the canonical Gs pathway and the alternative β arrestin 2 (βarr2) pathway.
Emilio Y. Lucero‐Garcia Rojas, Arfaxad Reyes‐Alcaraz, Kehe Ruan, Bradley K. McConnell, Richard A. Bond   +4 more
wiley   +1 more source

Low-Dose Propranolol Prevents Functional Decline in Catecholamine-Induced Acute Heart Failure in Rats

Toxics, 2022
Severe hyper-catecholaminergic states likely cause heart failure and cardiac fibrosis. While previous studies demonstrated the effects of beta-blockade in experimental models of single-catecholamine excess states, the detailed benefits of beta-blockade ...
Cheng-Ken Tsai, Bo-Hau Chen, Hsin-Hung Chen, Rebecca Jen-Ling Hsieh, Jui-Chen Lee, Yi-Ting Chu, Wen-Hsien Lu   +6 more
doaj   +1 more source

Involvement of propranolol in suicides: cross-sectional study using coroner-reported data

BJPsych Open
Background Propranolol is a beta-blocker medication indicated mostly for heart rhythm conditions and for physical symptoms of anxiety. Prescriptions for propranolol in the UK have increased since 2008.
Hayley C. Gorton, Charlotte Archer, Thikra Algahtani, Faraz Mughal, Caroline S. Copeland   +4 more
doaj   +1 more source