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Learning from OCTET – exploring the acceptability of clinical trials management methods
Trials, 2018 Background Conducting research can be time consuming, difficult and challenging. Guidance and pragmatic advice focussing on randomised controlled trial conduct are available but do not necessarily constitute comprehensive guidance.
Catherine Arundel, Judith Gellatly
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Fish oil (n-3 fatty acids) in drug resistant epilepsy: a randomised placebo-controlled crossover study. [PDF]
, 2014 Backgroundn-3 fatty acids inhibit neuronal excitability and reduce seizures in animal models. High-dose fish oil has been explored in two randomised trials in drug resistant epilepsy with negative results.
DeGiorgio, Christopher M +6 more
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Limitations of randomised controlled trials [PDF]
BMJ, 1995 EDITOR,—T C B Dehn has commented on the problems of accruing patients into randomised controlled trials, noting the understandable reluctance of patients to enter some trials (“I want the best treatment, doctor”) in which the patient's outcome (for example, time to death) is the main end point and, consequently, the patient is unable to benefit from ...
R. H. Grace +2 more
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The SMILES trial: an important first step
BMC Medicine, 2018 The SMILES trial was the first intervention study to test dietary improvement as a treatment strategy for depression. Molendijk et al. propose that expectation bias and difficulties with blinding might account for the large effect size.
Felice N. Jacka +13 more
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Non-strategic ignorance: Considering the potential for a paradigm shift in evidence-based mental health [PDF]
, 2018 Randomised controlled trials form a central building block within the prevailing evidence-based mental health paradigm. Both methodology and paradigm have been widely problematised since their emergence in the mid-late twentieth century.
Cochrane A +12 more
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Website of the week: Randomised controlled trials [PDF]
BMJ, 1999 This week, a series of four articles considers the place of the randomised controlled trial as we approach the second century of experience with the concept. Its basic principle is genuine uncertainty as to which treatment arm of the trial it would be in a patient's best interests to enter. This is not necessarily an easy concept to transmit, …
openaire +3 more sources
Research Integrity and Peer Review, 2019 Background The ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the ...
Kaitlyn Hair +3 more
doaj +1 more source
Lovastatin for adult patients with dengue: protocol for a randomised controlled trial. [PDF]
, 2012 BACKGROUND: Dengue is the most important vector-borne viral infection of man, with approximately 2 billion people living in areas at risk. Infection results in a range of manifestations from asymptomatic infection through to life-threatening shock and ...
Dung, Nguyen Thi Phuong +12 more
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Design considerations for clinical trials in aphasia
Annals of Indian Academy of Neurology, 2020 The use of the randomised controlled trial (RCT) design to evaluate the effectiveness of new interventions in aphasia has increased in recent years in response to calls for high quality evidence of the effectiveness of interventions for this population ...
Rebecca Palmer
doaj +1 more source
Trials, 2017 Background Distal femoral fractures are a source of considerable morbidity and best treatment is currently uncertain. The Trial of Acute Femoral Fracture Fixation (TrAFFix) is a randomised, parallel-group feasibility study designed to inform the design ...
Xavier L. Griffin +5 more
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