Results 21 to 30 of about 1,241,741 (325)

The effect of Bu Zhong Yi Qi decoction on simulated weightlessness‑induced muscle atrophy and its mechanisms. [PDF]

Mol Med Rep, 2017
Microgravity has been previously demonstrated to induce skeletal muscle atrophy, loss of muscle force and disorders in myogenesis and metabolism. Current pharmacological strategies exhibit poor efficacy.
Zhu M, Liu Z, Gao M, Zhang Y, Li Y, Ling S, Zhang P, Zhao C, Jiang L, Liu Y, Li Q, Li D, Hu S, Li Y.   +13 more
europepmc   +4 more sources

Tapping into rhythm generation circuitry in humans during simulated weightlessness conditions [PDF]

Frontiers in Systems Neuroscience, 2015
An ability to produce rhythmic activity is ubiquitous for locomotor pattern generation and modulation. The role that the rhythmogenesis capacity of the spinal cord plays in injured populations has become an area of interest and systematic investigation ...
Irina eSolopova, Victor eSelionov, Francesca eSylos Labini, Victor eGurfinkel, Francesco eLacquaniti, Yuri P Ivanenko   +5 more
doaj   +4 more sources

Simulated Weightlessness Induces Hippocampal Insulin Resistance and Cognitive Impairment

Life Sciences, 2023
Growing evidence highlights the potential consequences of long-term spaceflight, including gray matter volume reduction and cognitive dysfunction with subclinical manifestations of diabetes mellitus among astronauts, but the underlying mechanisms remain unknown. In this study, we found that long-term simulated weightlessness induced hippocampal insulin
Jiahui Li, Caiyan Xue, Hongyan Yang, Jiaxin Zhang, Guohua Li, Jijun Li, Fang Kuang, Jing Chen, Shu Zhang, Feng Gao, Zhenzhen Kou, Xing Zhang, Ling Dong   +12 more
semanticscholar   +4 more sources

Effects of Ginsenoside Rb1 on the Crosstalk between Intestinal Stem Cells and Microbiota in a Simulated Weightlessness Mouse Model. [PDF]

Int J Mol Sci
Exposure to the space microenvironment has been found to disrupt the homeostasis of intestinal epithelial cells and alter the composition of the microbiota.
Zong B, Wang J, Wang K, Hao J, Han JY, Jin R, Ge Q.   +6 more
europepmc   +2 more sources

Effects of real and simulated weightlessness on the cardiac and peripheral vascular functions of humans: A review [PDF]

International Journal of Occupational Medicine and Environmental Health, 2015
Weightlessness is an extreme environment that can cause a series of adaptive changes in the human body. Findings from real and simulated weightlessness indicate altered cardiovascular functions, such as reduction in left ventricular (LV) mass, cardiac ...
Hui Zhu, Hanqing Wang, Zhiqiang Liu
doaj   +2 more sources

Involvement of Cholinergic Dysfunction and Oxidative Damage in the Effects of Simulated Weightlessness on Learning and Memory in Rats. [PDF]

Biomed Res Int, 2018
The present study aimed to determine how the learning and memory gradually change with the prolonged hindlimb unloading (HU) treatment in rats. Different HU durations (7 d, 14 d, 21 d, and 28 d) in Sprague-Dawley (SD) rats were implemented.
Zhang Y, Wang Q, Chen H, Liu X, Lv K, Wang T, Wang Y, Ji G, Cao H, Kan G, Li Y, Qu L.   +11 more
europepmc   +2 more sources

Impact of microgravity on retinal neuroimmune responses and visual dysfunction in rats [PDF]

International Journal of Ophthalmology
AIM: To analyze visual dysfunction in rats under simulated weightlessness (SW) by examining trans-laminar cribrosa pressure difference (TLCPD) and neuroimmune responses.
Jin-Shuo Liu, Nai-Qin Yan, Ying-Yan Mao, Chen Xin, Da-Peng Mou, Xin-Xiao Gao, Jia Guo, Ning-Li Wang, Si-Quan Zhu   +8 more
doaj   +2 more sources

Research on the Specificity of Electrophysiological Signals of Human Acupoints Based on the 90-Day Simulated Weightlessness Experiment on the Ground

IEEE transactions on neural systems and rehabilitation engineering, 2021
Acupoint specificity for diseases has consistently been the focus of acupuncture research owing to its excellent prospects for clinical diagnosis and treatment. However, the specificity of cardiovascular and sleep functions in terms of electrical signals
Yun Wang, Zhiqi Fan, Mixia Wang, Juntao Liu, Shengwei Xu, Zeying Lu, Hao Wang, Yilin Song, Yiding Wang, Lina Qu, Yinghui Li, Xinxia Cai   +11 more
openalex   +2 more sources

Administration of Essential Phospholipids Prevents Drosophila Melanogaster Oocytes from Responding to Change in Gravity [PDF]

Cells
The aim of this study was to prevent initial changes in Drosophila melanogaster oocytes under simulated weightlessness and hypergravity at the 2 g level.
Ksenia K. Gogichaeva, Irina V. Ogneva
doaj   +2 more sources

<i>Polygonatum sibiricum</i> Polysaccharides Alleviate Simulated Weightlessness-Induced Cognitive Impairment by Gut Microbiota Modulation and Suppression of NLRP3/NF-κB Pathways. [PDF]

Nutrients
Chen F, Khan MN, Xie M, Zhang Y, Li L, Dar Farooq A, Liu J, He Q, Liu X, Jiang N.   +9 more
europepmc   +3 more sources