Results 21 to 30 of about 6,608 (237)

Tropoelastin production and tropoelastin messenger RNA activity. Relationship to copper and elastin cross-linking in chick aorta [PDF]

Biochemical Journal, 1986
The elastin content of the chick thoracic aorta increases 2--3-fold during the first 3 weeks post-hatching. The deposition of elastin requires the covalent cross-linking of tropoelastin by means of lysine-derived cross-links. This process is sensitive to dietary copper intake, since copper serves as cofactor for lysyl oxidase, the enzyme that catalyses
David O. Tinker, Joshua S. Geller, N. Romero, C E Cross, Robert B. Rucker   +4 more
openalex   +4 more sources

TriHex 2.0-Advancing Skin Health Science and the TriHex Technology. [PDF]

J Cosmet Dermatol
ABSTRACT Background The original TriHex combination—Tripeptide‐1 and Hexapeptide‐12 (TriHex) encompasses a peptide combination selected for its ability to modulate the extracellular matrix (ECM) by progressively eliminating clumped collagen and elastin fragments and then stimulating replacement with new collagen and elastin.
Widgerow AD, Ziegler ME, Shafiq F.
europepmc   +2 more sources

A Comparison of the Mechanical Properties of ECM Components and Synthetic Self-Assembling Peptides. [PDF]

Adv Healthc Mater
Self‐assembling peptide hydrogels are increasingly utilized in biomedical applications. The authors review the key mechanical properties of these structures across multiple size scales and compare them to that of native extracellular matrix components, which are found to display a much wider range of structural attributes.
Hartley A, Williams PM, Mata A.
europepmc   +2 more sources

Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

Frontiers in Materials, 2021
Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi, Lubinda Mbundi, Miguel González-Pérez, Fernando González-Pérez, Diana Juanes-Gusano, José Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source

Fibrous Scaffolds From Elastin-Based Materials

Frontiers in Bioengineering and Biotechnology, 2021
Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to
Jose Carlos Rodriguez-Cabello, Jose Carlos Rodriguez-Cabello, Israel Gonzalez De Torre, Israel Gonzalez De Torre, Miguel González-Pérez, Miguel González-Pérez, Fernando González-Pérez, Fernando González-Pérez, Irene Montequi, Irene Montequi   +9 more
doaj   +1 more source

Biochemistry of tropoelastin [PDF]

European Journal of Biochemistry, 1998
Elastic fibres are an important component of the extracellular matrix and are made of two major components : the more abundant cross‐linked elastic protein elastin and the multi‐component microfibrils. The biosynthesis of elastic fibres is a complex process involving the interplay of many diverse proteins and genes with elastin as the major component ...
Bernadette Vrhovski, Anthony S. Weiss
openaire   +3 more sources

Developmental regulation of tropoelastin isoforms.

Journal of Biological Chemistry, 1988
The production of tropoelastin isoforms was examined by cell-free translation of nuchal ligament RNA from cows of various ages ranging from 110 days of gestation to adult. Tropoelastin polypeptides synthesized in vitro were immunoprecipitated with a specific monoclonal antibody and separated by high resolution sodium dodecyl sulfate-polyacrylamide gel ...
William C. Parks, Heather Secrist, Lai‐Chu Wu, Robert P. Mecham   +3 more
openalex   +4 more sources

Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. [PDF]

PLoS ONE, 2017
Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix components ...
Stephanie E Seidl, Lawrence G Pessolano, Christopher A Bishop, Michael Best, Celeste B Rich, Phillip J Stone, Barbara M Schreiber   +6 more
doaj   +1 more source

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Frontiers in Genetics, 2021
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin.
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss, Clair Baldock   +7 more
doaj   +1 more source

Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16

Archives of Medical Science, 2020
Introduction Androgenetic alopecia (AGA) or male pattern baldness is a polygenic disease with a high prevalence in the Caucasian population, with psychosocial implications. However, the molecular mechanisms involved are unknown. The aim of this study was
Miguel A. Ortega, María J. Álvarez-Rocha, Ángel Asúnsolo, Beatriz Romero, Santiago Coca, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla   +7 more
doaj   +1 more source