Results 31 to 40 of about 252,333 (374)

FMRP mediates mGluR5-dependent translation of amyloid precursor protein. [PDF]

PLoS Biology, 2007
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Abeta) accumulation, which is associated with Alzheimer disease, results in synaptic loss and impaired neurotransmission.
Cara J Westmark, James S Malter
doaj   +1 more source

Regressive Autism Spectrum Disorder: High Levels of Total Secreted Amyloid Precursor Protein and Secreted Amyloid Precursor Protein-α in Plasma

Frontiers in Psychiatry, 2022
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social communication difficulties, repetitive behaviors, and parochial interests.
Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Xiaoli Li, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Ping Zhou, Qiu Li, Qiu Li, Qiu Li, Qiu Li, Bin Peng, Yupeng Cun, Yupeng Cun, Yupeng Cun, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Ying Dai, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Hua Wei, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Xiao Liu, Yang Yu, Yang Yu, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Zhiyang Jiang, Qiongli Fan, Yuping Zhang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Ting Yang, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Jie Chen, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Qian Cheng, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Tingyu Li, Li Chen, Li Chen, Li Chen, Li Chen, Li Chen   +66 more
doaj   +1 more source

Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease.

Cold Spring Harbor Perspectives in Medicine, 2017
Alzheimer's disease (AD) is characterized neuropathologically by neuronal cell loss, extracellular neuritic plaques composed of β-amyloid (Aβ), and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein.
J. Tcw, A. Goate
semanticscholar   +1 more source

The amyloid precursor protein is a conserved Wnt receptor

eLife, 2021
The Amyloid Precursor Protein (APP) and its homologues are transmembrane proteins required for various aspects of neuronal development and activity, whose molecular function is unknown. Specifically, it is unclear whether APP acts as a receptor, and if so what its ligand(s) may be.
Tingting Zhang, Tingting Zhang, Marie-Claude Potier, Annelies Claeys, Maya Nicolas, Tengyuan Liu, Tengyuan Liu, Lee G. Fradkin, Iveta M. Petrova, Bart De Strooper, Bart De Strooper, Bassem A. Hassan, Lydie Boussicault, Heather C. Rice, Alessia Soldano   +14 more
openaire   +8 more sources

Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease

eNeuro, 2017
It is widely accepted that amyloid β (Aβ) generated from amyloid precursor protein (APP) oligomerizes and fibrillizes to form neuritic plaques in Alzheimer’s disease (AD), yet little is known about the contribution of APP to intracellular signaling ...
Lisa Kirouac, Alexander J. Rajic, D. Cribbs, J. Padmanabhan   +3 more
semanticscholar   +1 more source

Acceleration of amyloid fibril formation by multichannel sonochemical reactor [PDF]

, 2021
Formation of amyloid fibrils of various amyloidogenic proteins is dramatically enhanced by ultrasound irradiation. For applying this phenomenon to the study of protein aggregation science and diagnosis of neurodegenerative diseases, a multichannel ultrasound irradiation system with individually adjustable ultrasound-irradiation conditions is necessary.
arxiv   +1 more source

Dual Action of Memantine in Alzheimer Disease: A Hypothesis

Taiwanese Journal of Obstetrics & Gynecology, 2009
Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
doaj   +1 more source

A Greek Tragedy: The Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis *

Journal of Biological Chemistry, 2016
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β.
Robert J Andrew, K. Kellett, G. Thinakaran, N. Hooper   +3 more
semanticscholar   +1 more source

Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein [PDF]

Journal of Biological Chemistry, 2006
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved ...
Neumann, Stephanie, Schöbel, Susanne, Jäger, Sebastian, Trautwein, Anna, Haass, Christian, Pietrzik, Claus U., Lichtenthaler, Stefan F.   +6 more
openaire   +3 more sources

Enzymatic Screening of β-Amyloid Precursor Protein-Based Substrates

Compounds, 2023
We performed an enzymatic screening of synthetic peptides based on β-amyloid precursor protein substrates. The template peptide sequence was a decapeptide derived from our previous screening study, which determined several effective unnatural amino acids.
Reo Yamada, Masaki Midorikawa, Ayu Asai, Norimasa Takasu, Ren Fujii, Taeko Kakizawa   +5 more
doaj   +1 more source