Results 31 to 40 of about 1,399,503 (222)

Fungal antigenic variation using mosaicism and reassortment of subtelomeric genes’ repertoires

Nature Communications, 2023
AbstractSurface antigenic variation is crucial for major pathogens that infect humans. To escape the immune system, they exploit various mechanisms. Understanding these mechanisms is important to better prevent and fight the deadly diseases caused.
Caroline S. Meier, Marco Pagni, Sophie Richard, Konrad Mühlethaler, João M. G. C. F. Almeida, Gilles Nevez, Melanie T. Cushion, Enrique J. Calderón, Philippe M. Hauser   +8 more
openaire   +7 more sources

Dectin-1-triggered Recruitment of Light Chain 3 Protein to Phagosomes Facilitates Major Histocompatibility Complex Class II Presentation of Fungal-derived Antigens*

Journal of Biological Chemistry, 2012
Background: Dectin-1 is a phagocytic receptor important for host immune responses to fungal infections. Results: Dectin-1 signaling directs LC3 to phagosomes leading to increased MHC class II recruitment and increased presentation of fungal-derived ...
Jun Ma, Courtney A. Becker, C. Lowell, D. Underhill   +3 more
semanticscholar   +1 more source

The effect of the treatment of denture related stomatitis on peripheral T cells and monocytes [PDF]

, 2017
Purpose: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely ...
Czesnikiewicz-Guzik, Marta, Maciag, Anna, Maciag, Joanna, Matusik, Pawel, Mikolajczyk, Tomasz, Nowakowski, Daniel, Osmenda, Grzegorz, Robertson, Douglas   +7 more
core   +1 more source

Use of Urine Antigen Testing for Blastomyces in an Integrated Health System

Journal of Patient-Centered Research and Reviews, 2018
Purpose: Blastomycosis, an endemic fungal infection, mimics many other diseases. We explored the use of Blastomyces urine antigen (BuAg), reportedly the most sensitive noninvasive test, in clinical practice and compared it to other noninvasive tests ...
Dennis J. Baumgardner
doaj   +1 more source

CD4(+) T cell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease.

Journal of Clinical Investigation, 2012
Aspergillus fumigatus is a model fungal pathogen and a common cause of infection in individuals with the primary immunodeficiency chronic granulomatous disease (CGD).
A. De Luca, R. Iannitti, S. Bozza, Rémi Beau, A. Casagrande, C. D’Angelo, S. Moretti, C. Cunha, Gloria Giovannini, Cristina Massi-Benedetti, A. Carvalho, L. Boon, J. Latgé, L. Romani   +13 more
semanticscholar   +1 more source

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance A newly discovered system for immunological detection of diverse bacterial and fungal pathogens involves the MHC-like host protein called MR1. This molecule scavenges metabolites from the biosynthesis of riboflavin by microbes.
Hamish E. G. McWilliam, Jeffrey Y. W. Mak, W. Awad, Matthew Zorkau, S. Cruz-Gomez, H. Lim, Yuting Yan, Sam Wormald, Laura F. Dagley, S. Eckle, A. Corbett, Haiyin Liu, Shihan Li, S. Reddiex, J. Mintern, Ligong Liu, J. McCluskey, J. Rossjohn, D. Fairlie, J. Villadangos   +19 more
semanticscholar   +1 more source

Novel Pneumocystis Antigen Discovery Using Fungal Surface Proteomics [PDF]

Infection and Immunity, 2014
ABSTRACT Pneumonia due to the fungus Pneumocystis jirovecii is a life-threatening infection that occurs in immunocompromised patients. The inability to culture the organism as well as the lack of an annotated genome has hindered antigen discovery that could be useful in developing novel vaccine- or ...
Yang Cai, David Ricks, Taylor Eddens, Mingquan Zheng, Jay K. Kolls   +4 more
openaire   +4 more sources

Structural basis of Blastomyces Endoglucanase-2 adjuvancy in anti-fungal and -viral immunity.

PLoS Pathogens, 2021
The development of safe subunit vaccines requires adjuvants that augment immunogenicity of non-replicating protein-based antigens. Current vaccines against infectious diseases preferentially induce protective antibodies driven by adjuvants such as alum ...
Lucas Dos Santos Dias, Hannah E Dobson, Brock Kingstad Bakke, Gregory C Kujoth, Junfeng Huang, Elaine M Kohn, Cleison Ledesma Taira, Huafeng Wang, Nitin T Supekar, J Scott Fites, Daisy Gates, Christina L Gomez, Charles A Specht, Stuart M Levitz, Parastoo Azadi, Lingjun Li, Marulasiddappa Suresh, Bruce S Klein, Marcel Wüthrich   +18 more
doaj   +1 more source

Aspergillus fumigatus preexposure worsens pathology and improves control of Mycobacterium abscessus pulmonary infection in mice [PDF]

, 2018
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and ...
Elsegeiny, Waleed, Gopal, Radha, Khader, Shabaana A, Kolls, Jay, McAleer, Jeremy P, Mehta, Shail, Monin, Leticia, Oury, Tim D   +7 more
core   +2 more sources

A Novel Insight into the Immunologic Basis of Chronic Granulomatous Invasive Fungal Rhinosinusitis

Allergy & Rhinology, 2016
Background Chronic granulomatous invasive fungal rhinosinusitis (CGIFRS) is a rare disease. The underlying immune responses that drive the development of CGIFRS, as opposed to successful pathogen clearance and controlled inflammation, are not currently ...
William Rae M.R.C.P., Rainer Doffinger F.R.C.Path., Fenella Shelton M.R.C.S., Eleanor Sproson F.R.C.S.(O.R.L.-H.N.S.), Hasnaa Ismail-Koch F.R.C.S.(O.R.L.-H.N.S.), Valerie J. Lund C.B.E., Philip G. Harries F.R.C.S.(O.R.L.-H.N.S.), Efrem Eren F.R.C.Path., Rami J. Salib F.R.C.S.(O.R.L.-H.N.S.)   +8 more
doaj   +1 more source