Results 31 to 40 of about 2,200,065 (287)

Caspase-7 deficiency in Chinese hamster ovary cells reduces cell proliferation and viability

Biological Research, 2020
Background Chinese hamster ovary (CHO) cells are the most commonly used mammalian host cell in the commercial-scale production of biopharmaceutical proteins. Modification of genes involved in apoptosis may improve the productivity of CHO cells. Executive
Fatemeh Safari, Safar Farajnia, Abbas Behzad Behbahani, Habib Zarredar, Mazyar Barekati-Mowahed, Hesam Dehghani   +5 more
doaj   +1 more source

Complex organic molecules in comets C/2012 F6 (Lemmon) and C/2013 R1 (Lovejoy): detection of ethylene glycol and formamide [PDF]

, 2014
A spectral survey in the 1 mm wavelength range was undertaken in the long-period comets C/2012 F6 (Lemmon) and C/2013 R1 (Lovejoy) using the 30 m telescope of the Institut de radioastronomie millim\'etrique (IRAM) in April and November-December 2013.
Biver, N., Bockelée-Morvan, D., Boissier, J., Colom, P., Crovisier, J., Debout, V., Lis, D. C., Moreno, R., Paubert, G., Russo, N. Dello, Vervack, R., Weaver, H. A.   +11 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Tình hình bệnh Parvovirus trên chó tại Bệnh xá Thú y - Trường Đại học Cần Thơ

Tạp chí Khoa học Đại học Cần Thơ, 2018
Thí nghiệm được tiến hành để xác định tỷ lệ nhiễm Canine Parvovirus (CPV) dựa vào kit chẩn đoán  nhanh CPV – Ag  trên chó từ 2 đến 6 tháng tuổi bị  tiêu chảy phân có lẫn máu tại Bệnh xá Thú y-Trường Đại học Cần Thơ.
Nguyễn Thị Yến Mai, Trần Văn Thanh, Trần Ngọc Bích   +2 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Development of cell lines producing recombinant therapeutic proteins, with denosumab as a case study

Биопрепараты: Профилактика, диагностика, лечение
INTRODUCTION. A key factor in the creation of biotechnological medicinal products is to establish cell lines for high-yield production of recombinant proteins.
S. S. Timonova, I. A. Kirik, M. A. Filatova, A. I. Anfilatova, S. S. Shubina, A. A. Polupanova, A. F. Gabdrakhmanova, E. S. Ivanov, V. N. Bade, A. A. Piskunov, R. A. Khamitov   +10 more
doaj   +1 more source

CD300LG improves the cytotoxic activity of CIK

Central European Journal of Immunology, 2017
To investigate the effect of CD300LG-γ induction on the cytotoxic activity of CIK. Eukaryotic expression plasmid hCD300LG-γ/pEGFP-C3, which can express human CD300LG-γ, was constructed and transfected into CHO cells by lipofectamine.
Qiuyue Wang, Yuqing Liu, Ying Chen, Ke Wang, Wensheng Xie, Dapeng Wei, Lijuan Hu   +6 more
doaj   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Effect of pre-exercise carbohydrate availability on fat oxidation and energy expenditure after a high-intensity exercise

Brazilian Journal of Medical and Biological Research, 2018
The aim of this study was to test the hypothesis that reduced pre-exercise carbohydrate (CHO) availability potentiates fat oxidation after an exhaustive high-intensity exercise bout. Eight physically active men underwent a high-intensity exercise (∼95% V̇
G.A. Ferreira, L.C. Felippe, R.L.S. Silva, R. Bertuzzi, F.R. De Oliveira, F.O. Pires, A.E. Lima-Silva   +6 more
doaj   +1 more source

The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells [PDF]

, 2005
The polarized distribution of Na+,K+-ATPase plays a paramount physiological role, because either directly or through coupling with co- and countertransporters, it is responsible for the net movement of, for example, glucose, amino acids, Ca2+, K+, Cl ...
Balda, MS, Cereijido, M, Contreras, RG, Lazaro, A, Matter, K, Moreno, J, Roldan, ML, Shoshani, L   +7 more
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