bioRxiv, 2019 Multiple sclerosis (MS) is a demyelinating, autoimmune disease of the central nervous system. While work has focused on axon loss in MS, far less is known about synaptic changes.
Sebastian Werneburg +10 more
semanticscholar +1 more source
The V5A13.1 envelope glycoprotein deletion mutant of mouse hepatitis virus type-4 is neuroattenuated by its reduced rate of spread in the central nervous system. [PDF]
, 1992 Following intracerebral inoculation of adult Balb/c Byj mice, the MHV-4 strain of mouse hepatitis virus (MHV) had an LD50 of less than 0.1 PFU, whereas its monoclonal antibody resistant variant V5A13.1 had an LD50 of 10(4.2) PFU.
Bloom, F +3 more
core +1 more source
The still under-investigated role of cognitive deficits in PML diagnosis [PDF]
, 2017 Background: Despite cognitive deficits frequently represent the first clinical manifestations of Progressive Multifocal Leukoencephalopathy (PML) in Natalizumab-treated MS patients, the importance of cognitive deficits in PML diagnosis is still under ...
Amato, Maria Pia +49 more
core +2 more sources
International Journal of General Medicine, 2021 Jian Li,1 Yi-Ming Zhao2 1Department of Neurology, Peking University Third Hospital, Beijing, 100191, People’s Republic of China; 2Center for Clinical Epidemiology, Peking University Third Hospital, Beijing, 100191, People’s Republic of ...
Li J, Zhao YM
doaj
Frontiers in Cellular and Infection Microbiology, 2018 CXCL-1, also called keratinocyte-derived cytokine (KC), is a predominant chemokine produced in glial cells upon infection with Theiler's murine encephalomyelitis virus (TMEV).
Min H. Kang, Young H. Jin, Byung S. Kim
doaj +1 more source
Mechanisms and treatment strategies of demyelinating and dysmyelinating Charcot-Marie-Tooth disease
Neural Regeneration Research, 2023 Schwann cells, the myelinating glia of the peripheral nervous system, wrap axons multiple times to build their myelin sheath. Myelin is of paramount importance for axonal integrity and fast axon potential propagation.
Nadège Hertzog, Claire Jacob
doaj +1 more source
Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. [PDF]
, 2018 Increasing evidence points to an important role for neutrophils in participating in the pathogenesis of the human demyelinating disease MS and the animal model EAE.
Doty, Daniel J +7 more
core +1 more source
Vitamin D Supplementation in Central Nervous System Demyelinating Disease—Enough Is Enough
International Journal of Molecular Sciences, 2019 The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual’s risk of developing this central nervous system (CNS) demyelinating disease and are associated with an acceleration in
Darius Häusler, Martin S. Weber
semanticscholar +1 more source
Frontiers in Immunology, 2017 Several lines of evidence suggest a definite and unique link between CNS demyelinating diseases and autoimmune thyroid disease (AITD). The aim of the current study was to systematically compare the clinical and laboratory features of patients with ...
Judith M. Greer +4 more
doaj +1 more source
Efficacy and safety of Privigen® in patients with chronic inflammatory demyelinating polyneuropathy: results of a prospective, single-arm, open-label Phase III study (the PRIMA study) [PDF]
, 2013 This prospective, multicenter, single-arm, open-label Phase III study aimed to evaluate the efficacy and safety of Privigen (R) (10% liquid human intravenous immunoglobulin [IVIG], stabilized with l-proline) in patients with chronic inflammatory ...
Bauhofer, Artur +12 more
core +1 more source