Results 31 to 40 of about 56,494 (234)
PLoS ONE, 2018 Dictyostelium has a mature technology for molecular-genetic manipulation based around transfection using several different selectable markers, marker re-cycling, homologous recombination and insertional mutagenesis, all supported by a well-annotated ...
Peggy I. Paschke +9 more
semanticscholar +1 more source
MAPKs in development: insights from Dictyostelium signaling pathways
Biomolecular Concepts, 2011 Mitogen activated protein kinases (MAPKs) play important roles in the development of eukaryotic organisms through the regulation of signal transduction pathways stimulated by external signals.
Hadwiger Jeffrey A., Nguyen Hoai-Nghia
doaj +1 more source
Disease Models & Mechanisms, 2018 Valproic acid (VPA) provides a common treatment for both epilepsy and bipolar disorder; however, common cellular mechanisms relating to both disorders have yet to be proposed.
Lin Song +10 more
semanticscholar +1 more source
Lysosomes appear as the auto-fluorescent vacuoles in Dictyostelium discoideum cells
Pteridines, 2016 Dictyostelium discoideum cells contain auto-fluorescent vacuoles. To determine the identity of these vacuoles, the fluorescent dye 4-nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole (NBD-PZ) was used to stain the lysosomes in D. discoideum cells. Neither the
Kainuma Hiroki +4 more
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Cell Sorting daring Pattern Formation in Dictyostelium [PDF]
, 1981 Formation of the prestalk-prespore pattern in Dictyostelium was investigated in slugs and submerged clumps of cells. Prestalk and prespore cells were identified by staining with vital dyes, which are shown to be stable cell markers.
David, Charles N., Sternfeld, John
core +1 more source
Acanthamoeba and Dictyostelium as Cellular Models for Legionella Infection
Frontiers in Cellular and Infection Microbiology, 2018 Environmental bacteria of the genus Legionella naturally parasitize free-living amoebae. Upon inhalation of bacteria-laden aerosols, the opportunistic pathogens grow intracellularly in alveolar macrophages and can cause a life-threatening pneumonia ...
A. L. Swart +4 more
semanticscholar +1 more source
CRISPR/Cas9 mediated targeting of multiple genes in Dictyostelium
Scientific Reports, 2018 CRISPR/Cas9 has emerged in various organisms as a powerful technology for targeted gene knockout; however, no reports of editing the Dictyostelium genome efficiently using this system are available.
R. Sekine, T. Kawata, Tetsuya Muramoto
semanticscholar +1 more source
Recent Insights into NCL Protein Function Using the Model Organism Dictyostelium discoideum
Cells, 2019 The neuronal ceroid lipofuscinoses (NCLs) are a group of devastating neurological disorders that have a global distribution and affect people of all ages.
Meagan D. McLaren +2 more
semanticscholar +1 more source
Models of aggregation in dictyostelium discoideum: On the track of spiral waves
Networks and Heterogeneous Media, 2006 This work is concerned with some aspects of the social life of theamoebae Dictyostelium discoideum (Dd). In particular, we shall focus on the early stages of the starvation-induced aggregation of Dd cells.
Miguel A. Herrero, Leandro Sastre
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Development of a Positive Selection High Throughput Genetic Screen in Dictyostelium discoideum
Frontiers in Cell and Developmental Biology, 2021 The cellular slime mold Dictyostelium discoideum is a powerful model organism that can be utilized to investigate human health and disease. One particular strength of Dictyostelium is that it can be utilized for high throughput genetic screens.
Felicia N. Williams +4 more
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