Results 31 to 40 of about 193,556 (316)

The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses

Cell Reports, 2017
Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces the IFN antiviral response. However, the regulatory mechanisms that mediate cGAS-triggered signaling have not been fully explored.
Michihiro Takahama, Mitsunori Fukuda, Norihiko Ohbayashi, Tatsuya Kozaki, Takuma Misawa, Toru Okamoto, Yoshiharu Matsuura, Shizuo Akira, Tatsuya Saitoh   +8 more
doaj   +1 more source

Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation

FEBS Letters, EarlyView.
Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley   +1 more source

The Chloroplast Ribonucleoprotein CP33B Quantitatively Binds the psbA mRNA

Plants, 2020
Chloroplast RNAs are stabilized and processed by a multitude of nuclear-encoded RNA-binding proteins, often in response to external stimuli like light and temperature. A particularly interesting RNA-based regulation occurs with the psbA mRNA, which shows
Marlene Teubner, Benjamin Lenzen, Lucas Bernal Espenberger, Janina Fuss, Jörg Nickelsen, Kirsten Krause, Hannes Ruwe, Christian Schmitz-Linneweber   +7 more
doaj   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Live-cell Microscopy and Fluorescence-based Measurement of Luminal pH in Intracellular Organelles

Frontiers in Cell and Developmental Biology, 2017
Luminal pH is an important functional feature of intracellular organelles. Acidification of the lumen of organelles such as endosomes, lysosomes, and the Golgi apparatus plays a critical role in fundamental cellular processes. As such, measurement of the
Li Ma, Li Ma, Qing Ouyang, Qing Ouyang, Gordon C. Werthmann, Heather M. Thompson, Heather M. Thompson, Heather M. Thompson, Eric M. Morrow, Eric M. Morrow, Eric M. Morrow   +10 more
doaj   +1 more source

Regulation of Organelle Biogenesis [PDF]

Cell, 1996
We are grateful to the members of the Walter laboratory and of the many other laboratories whose work is reviewed for their helpful discussions, for their critical reading of this manuscript, and for making preprints available prior to publication. Because of space limitations, we were not able to include many of the primary references, and the readers
Jodi Nunnari, Peter Walter
openaire   +3 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Cell biological insights into human STING variants

Cell Structure and Function
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER)-localized transmembrane protein. STING induces type I interferon and inflammatory responses against a variety of double-stranded DNA (dsDNA) viruses, which is critical for limiting ...
Shogo Koide, Eisuke Yumoto, Jun Nakayama, Shigeki Higashiyama, Yoshihiko Kuchitsu, Tomohiko Taguchi   +5 more
doaj   +1 more source

An organelle knockout [PDF]

The Journal of Cell Biology, 2001
![Graphic][1] Swimming is a problem despite remaining lipid rafts. Kurzchalia/AAAS By knocking out a single gene for caveolin-1, Teymuras Kurzchalia (Max Planck Institute, Dresden, Germany) and colleagues have ablated a special subset of lipid rafts called caveolae.
openaire   +2 more sources

Cilia - the prodigal organelle [PDF]

Cilia, 2012
Cilia are the oldest known cellular organelle, first described in 1675 by Anthony van Leeuwenhoek in protozoa [1]. He described them as 'incredibly thin feet, or little legs, which were moved very nimbly'. The term 'cilium' (Latin for eyelash) was probably first coined by Otto Muller in 1786 [2].
Peter K. Jackson, PL Beales
openaire   +3 more sources