Results 31 to 40 of about 120,800 (295)

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

Proceedings of the National Academy of Sciences of the United States of America, 1983
A syndrome similar to idiopathic parkinsonism developed after intravenous self-administration of an illicit drug preparation in which N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (NMPTP) might have been responsible for the toxicity.
Burns Rs, C. Chiueh, S. Markey, M. Ebert, D. Jacobowitz, I. Kopin   +5 more
semanticscholar   +1 more source

Identification of proteins in human substantia nigra [PDF]

PROTEOMICS – Clinical Applications, 2008
AbstractCharacterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD ...
Kitsou, Efstathia, Pan, Sheng, Zhang, Jian Peng, Shi, Min, Zabeti, Aram, Dickson, Dennis W., Albin, Roger L., Gearing, Marla, Kashima, Daniel T., Wang, Yan, Beyer, Richard P., Zhou, Yong, Pan, Catherine, Caudle, W. Michael, Zhang, Jing   +14 more
openaire   +4 more sources

Depth‐Customizable 3D Electrode Array for Recording Functional Connectivity in the Brain

Advanced Electronic Materials, EarlyView.
In this study, a depth‐adjustable, flexible 3D multi‐shank electrode array that produces precise neural recordings at various brain depths is developed. Integrating 2D flexible electrode arrays with a modular supporting board allowed the insertion depth to be easily adjusted without re‐fabrication.
Minseok Kim, Sehwan Park, Haeyun Lee, Jimin Lee, Namsun Chou, Hyogeun Shin   +5 more
wiley   +1 more source

The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease.

Brain : a journal of neurology, 1999
To achieve accuracy in studying the patterns of loss of midbrain dopamine-containing neurons in Parkinson's disease, we used compartmental patterns of calbindin D(28K) immunostaining to subdivide the substantia nigra with landmarks independent of the ...
P. Damier, E. Hirsch, Y. Agid, A. Graybiel   +3 more
semanticscholar   +1 more source

Cistanche tubulosa improves peripheral neuropathy in MPTP‐induced PD mice based on regulation of m6A methylation

Animal Models and Experimental Medicine, EarlyView.
At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li, Wei Jia, Junhua Hu, Borui Zhang, Xinxin Qi, Jianhua Yang, Xinling Yang   +6 more
wiley   +1 more source

Similar Roles of Substantia Nigra and Ventral Tegmental Dopamine Neurons in Reward and Aversion

Journal of Neuroscience, 2014
Dopamine neurons in the ventral tegmental area (VTA) are implicated in affective functions. However, it is unclear to what extent dopamine neurons in substantia nigra pars compacta (SNc) play such roles.
A. Ilango, Andrew J. Kesner, Kristine L. Keller, G. Stuber, A. Bonci, S. Ikemoto   +5 more
semanticscholar   +1 more source

Establishment of a humanized SCA2 mouse model carrying a CAA disruption preventing CAG repeat expansion in pathogenic genes

Animal Models and Experimental Medicine, EarlyView.
In this study, we established a mouse model in which CAG repeats do not undergo microsatellite instability (MSI) across generations. A humanized ATXN2 cDNA with four CAA interruptions within 73 CAG expansions was inserted into the Rosa26 locus of C57BL/6J mice. At the same time, a 23 CAG control mouse model was also generated.
Yao Zhang, Yufei Li, Lin Zhang, Zhaoqing Li, Keqin Lin, Kai Huang, Zhaoqing Yang, Shaohui Ma, Hao Sun, Xiaochao Zhang   +9 more
wiley   +1 more source

Research advances in dysphagia animal models

Animal Models and Experimental Medicine, EarlyView.
This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai, Keling Cheng, Nannan Zhang, Yunfang Chen, Jun Ni, Zhiyong Wang   +5 more
wiley   +1 more source

Beitrag zur vergleichenden Anatomie der Substantia nigra, des Corpus Luysii und der Zona incerta. (Fortsetzung.) [PDF]

, 1910
Torata Sano
openalex   +2 more sources

MR imaging of the substantia nigra at 7 T enables diagnosis of Parkinson disease.

Radiology, 2014
PURPOSE To evaluate the anatomy of the substantia nigra (SN) in healthy subjects by performing 7-T magnetic resonance (MR) imaging of the SN, and to prospectively define the accuracy of 7-T MR imaging in distinguishing Parkinson disease (PD) patients ...
M. Cosottini, D. Frosini, I. Pesaresi, M. Costagli, L. Biagi, R. Ceravolo, U. Bonuccelli, M. Tosetti   +7 more
semanticscholar   +1 more source