Results 41 to 50 of about 601,814 (124)
On the impact of Masking and Blocking Hypotheses for measuring efficacy of new tuberculosis vaccines [PDF]
arXiv, 2015 Over the past 60 years, the Mycobacterium bovis bacille Calmette-Gu\'erin (BCG) has been used worldwide to prevent tuberculosis (TB). However, BCG has shown a very variable efficacy in different trials, showing a wide range of protection in adults against pulmonary TB.
arxiv
A Data Mining Approach to the Diagnosis of Tuberculosis by Cascading Clustering and Classification [PDF]
Journal of computing, volume 3, issue 4,April 2011, ISSN 2151-9617, 2011 In this paper, a methodology for the automated detection and classification of Tuberculosis(TB) is presented. Tuberculosis is a disease caused by mycobacterium which spreads through the air and attacks low immune bodies easily. Our methodology is based on clustering and classification that classifies TB into two categories, Pulmonary Tuberculosis(PTB ...
arxiv
Journal of Experimental Medicine, 2016 Russell et al. show that activation of Mycobacterium tuberculosis–infected macrophages in vitro and in vivo enhances drug tolerance and renders the bacilli more refractory to drug-dependent killing.
Yancheng Liu +9 more
semanticscholar +1 more source
Metabolic anticipation in Mycobacterium tuberculosis
Nature Microbiology, 2017 Humans serve as both host and reservoir for Mycobacterium tuberculosis, making tuberculosis a theoretically eradicable disease. How M. tuberculosis alternates between host-imposed quiescence and sporadic bouts of replication to complete its life cycle ...
Hyungjin Eoh +7 more
semanticscholar +1 more source
A Diarylquinoline Drug Active on the ATP Synthase of Mycobacterium tuberculosis
Science, 2005 The incidence of tuberculosis has been increasing substantially on a worldwide basis over the past decade, but no tuberculosis-specific drugs have been discovered in 40 years.
K. Andries +17 more
semanticscholar +1 more source
Analysis of DevR regulated genes in Mycobacterium tuberculosis [PDF]
arXiv, 2013 The DevRS two component system of Mycobacterium tuberculosis is responsible for its dormancy in host and becomes operative under hypoxic condition. It is experimentally known that phosphorylated DevR controls the expression of several downstream genes in a complex manner.
arxiv
VapCs of Mycobacterium tuberculosis cleave RNAs essential for translation
Nucleic Acids Research, 2016 The major human pathogen Mycobacterium tuberculosis can survive in the host organism for decades without causing symptoms. A large cohort of Toxin–Antitoxin (TA) modules contribute to this persistence.
K. Winther +3 more
semanticscholar +1 more source
An essential role for interferon gamma in resistance to Mycobacterium tuberculosis infection
Journal of Experimental Medicine, 1993 Tuberculosis, a major health problem in developing countries, has reemerged in recent years in many industrialized countries. The increased susceptibility of immunocompromised individuals to tuberculosis, and many experimental studies indicate that T ...
J. Flynn +5 more
semanticscholar +1 more source
Nature Communications, 2015 The rise of antibiotic-resistant bacteria has led to an urgent need for rapid detection of drug resistance in clinical samples, and improvements in global surveillance. Here we show how de Bruijn graph representation of bacterial diversity can be used to
Phelim Bradley +27 more
semanticscholar +1 more source
Efficient and Accurate Tuberculosis Diagnosis: Attention Residual U-Net and Vision Transformer Based Detection Framework [PDF]
arXivTuberculosis (TB), an infectious disease caused by Mycobacterium tuberculosis, continues to be a major global health threat despite being preventable and curable. This burden is particularly high in low and middle income countries. Microscopy remains essential for diagnosing TB by enabling direct visualization of Mycobacterium tuberculosis in sputum ...
arxiv