Results 41 to 50 of about 65,888 (300)
Frontiers in Immunology, 2019 The G protein-coupled P2Y11 receptor is known to sense extracellular ATP during inflammatory and immune responses. The dinucleotide NAD+ has also been proposed to be a P2Y11 receptor ligand but its role is less clear. Here, we have examined for the first
Georg Gruenbacher +7 more
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Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage
Nature Communications, 2019 Nicotinamide adenine dinucleotide (NAD+) sustains cellular energy metabolism, functions as a substrate of Sirt and PARP enzymes, and its supplementation is explored therapeutically in aging and other contexts.
Audrey Sambeat +12 more
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Biomolecules, 2022 Cisplatin is an FDA approved anti-cancer drug that is widely used for the treatment of a variety of solid tumors. However, the severe adverse effects of cisplatin, particularly kidney toxicity, restrict its clinical and medication applications. The major
Amany Iskander, Liang-Jun Yan
doaj +1 more source
Evidence for two NAD kinases in Salmonella typhimurium [PDF]
Journal of Bacteriology, 1994 The electron-carrying cofactor NADP is formed by phosphorylation of NAD. A strategy for the isolation of NAD kinase mutants revealed two classes of temperature-sensitive mutations, nadF and nadG, mapping at min 13 and 72 of the Salmonella chromosome.
Weili Cheng, John R. Roth
openaire +3 more sources
The CreC regulator of Escherichia coli, a new target for metabolic manipulations [PDF]
, 2015 The CreBC (carbon source-responsive) two-component regulation system of Escherichia coli affects a number of functions, including intermediary carbon catabolism.
Cabrera Gomez, José Gregorio +3 more
core +1 more source
Frontiers in Endocrinology, 2022 Cellular senescence is a stress or damage response by which a cell adopts of state of essentially permanent proliferative arrest, coupled to the secretion of a number of biologically active molecules. This senescence-associated secretory phenotype (SASP)
Chisaka Kuehnemann +8 more
doaj +1 more source
Sensitive superoxide detection in vascular cells by the new chemiluminescence dye L-012 [PDF]
, 1999 The detection superoxide production in vascular cells is usually limited by a low sensitivity of available assays, We tested the applicability of the luminol derivate L-012 {[}8-amino-5-chloro-7-phenylpyridol{[}3,4-d]pyridazine-l,4(2H,3H)dione] to ...
Gloe, Torsten +4 more
core +1 more source
Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]
, 2015 Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk +9 more
core +1 more source
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase
, 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson +47 more
core +1 more source
Minimizing acetate formation in E. coli fermentations [PDF]
, 2007 Escherichia coli remains the best established production organisms in industrial biotechnology. However, during aerobic fermentation runs at high growth rates, considerable amounts of acetate are accumulated as by-product.
De Maeseneire, Sofie +3 more
core +2 more sources