Results 41 to 50 of about 438,619 (385)

First High-Resolution Crystal Structures of DNA:2′-O-Methyl-RNA Heteroduplexes

Crystals, 2022
Heteroduplexes composed of all-DNA and all-2′-OMe RNA strands do not occur in nature, but they have found application in the development of molecular beacons and could also be used as aptamers or elements of nucleic acid-based nanostructures that will ...
Rafał Dolot, Anna Maciaszek, Barbara Mikołajczyk, Barbara Nawrot   +3 more
doaj   +1 more source

Molecular Rotors: Fluorescent Sensors for Microviscosity and Conformation of Biomolecules

Angewandte Chemie, 2023
The viscosity and crowding of biological environment are considered vital for the correct cellular function, and alterations in these parameters are known to underly a number of pathologies including diabetes, malaria, cancer and neurodegenerative ...
Miguel Paez-Perez, M. Kuimova
semanticscholar   +1 more source

Biophysical and electrochemical studies of protein-nucleic acid interactions [PDF]

, 2015
This review is devoted to biophysical and electrochemical methods used for studying protein-nucleic acid (NA) interactions. The importance of NA structure and protein-NA recognition for essential cellular processes, such as replication or transcription ...
A Abi, A Aravin, A Danhel, A Danhel, A Re, A Simonova, A Szabo, AA Gorodetsky, AA Travers, AL Feig, AM Cobb, AN Kawde, Andrew M. Cobb, B Deng, B Dey, B McConnell, BOS Scott, C Schildkraut, CA Hunter, CN N’Soukpoe-Kossi, CR Calladine, CS Yeh, D Rhodes, DB Dogini, DG Brown, DJ Richard, DK Hendrix, E Farjami, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Palecek, E Stejskalova, EB Jagelska, EB Jagelska, EJ Nam, EM Boon, EM Boon, EM Boon, FU Hartl, G Zauner, GP Yan, H Cahova, H Pivonkova, Hana Pivonkova, HF Wang, J Balintova, J Balintova, J Batra, J Coufal, J Labuda, J Majka, J Vacek, J Wang, JA McClellan, JD Puglisi, JL Wang, JL Wang, K Cahova-Kucharikova, K Nemcova, K Nemcova, K Teilum, KV Morris, L Havran, L Jen-Jacobson, LD Hansen, LL Pang, LM Hellman, Ludek Havran, M Bartosik, M Brazdova, M Brazdova, M Brenowitz, M Fojta, M Fojta, M Fojta, M Fojta, M Fojta, M Fojta, M Fojta, M Fojta, M Heyrovsky, M Hocek, M Kampmann, M Masarik, M Oda, M Willander, Miroslav Fojta, NB Leontis, NB Muren, NC Seeman, NN Salim, O Bell, P Zhang, PA Garrity, PC Weber, PH Hippel von, PH Hippel von, PJ Hagerman, R Christova, R Kaptein, RE Dickerson, Richard P. Bowater, RJ Falconer, RP Bowater, S Khezrian, S Lee, S Tan, SA Coulocheri, SE Halford, SR Holbrook, SR Rajski, T Hianik, TM Hall, TS Furey, V Brazda, V Ostatna, V Petri, V Ramakrishnan, V Vargova, W Filipowicz, WD Kohn, XB Yin, XX He, Y Xiao, Y Xiao, Y Zhang, YH Xu, Z Yang, ZS Wu   +136 more
core   +1 more source

Microgels and apparatus for PAGE of nucleic acids in one or two dimensions

BioTechniques, 2018
We describe a system for horizontal 1D or 2D PAGE comprising an apparatus and microgels. There is no buffer outside the gel, making handling and sample loading easy.
Hans G Thormar, Gudmundur H Gunnarsson, Bjarki Gudmundsson, Kristjan Leosson, Peter Estibeiro, Jon J Jonsson   +5 more
doaj   +1 more source

T7 RNA polymerase functions in vitro without clustering. [PDF]

PLoS ONE, 2012
Many nucleic acid polymerases function in clusters known as factories. We investigate whether the RNA polymerase (RNAP) of phage T7 also clusters when active.
Kieran Finan, Joseph P Torella, Achillefs N Kapanidis, Peter R Cook   +3 more
doaj   +1 more source

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids. [PDF]

, 2015
Telomerase is an enzyme that adds repetitive DNA sequences to the ends of chromosomes and consists of two main subunits: the telomerase reverse transcriptase (TERT) protein and an associated telomerase RNA (TER). The telomerase essential N-terminal (TEN)
Akiyama, Benjamin M, Parks, Joseph W, Stone, Michael D   +2 more
core   +2 more sources

IFITs: Emerging Roles As Key Anti-Viral Proteins

Frontiers in Immunology, 2014
Interferon-induced protein with tetratricopeptide repeats (IFITs) are a family of proteins which are strongly induced downstream of type I interferon (IFN) signaling.
Gregory I Vladimer, Maria W Górna, Giulio eSuperti-Furga   +2 more
doaj   +1 more source

Structure of an archaeal PCNA1-PCNA2-FEN1 complex: elucidating PCNA subunit and client enzyme specificity. [PDF]

, 2006
The archaeal/eukaryotic proliferating cell nuclear antigen (PCNA) toroidal clamp interacts with a host of DNA modifying enzymes, providing a stable anchorage and enhancing their respective processivities.
Andrew S. Doré, Antony W. Oliver, Brunger, Bunting, CCP4, Chang, Chapados, Dalrymple, DeLano, Dianova, Dionne, Dionne, Emsley, Friedrich-Heineken, Gulbis, Helt, Hingorani, Hosfield, Kelman, Kong, Kontopidis, Krishna, Krokan, Laurence H. Pearl, Leslie, Mairi L. Kilkenny, Matsumiya, Matsumoto, Murante, Murshudov, Oyama, Parker, Parrilla-Castellar, Pearl, Roberts, S. Mark Roe, Sakurai, Sarah A. Jones, Shamoo, Shen, Smirnova, Stephen D. Bell, Storoni, Tom, Toueille, Tsuchimoto, Venclovas, Volkmer, Wang   +48 more
core   +4 more sources

Lone Pair…π Contacts and Structure Signatures of r(UNCG) Tetraloops, Z-Turns, and Z-Steps: A WebFR3D Survey

Molecules, 2022
Z-DNA and Z-RNA have long appeared as oddities to nucleic acid scientists. However, their Z-step constituents are recurrently observed in all types of nucleic acid systems including ribosomes.
Craig L. Zirbel, Pascal Auffinger
doaj   +1 more source

Use of Nucleic Acid Analogs for the Study of Nucleic Acid Interactions

Journal of Nucleic Acids, 2011
Unnatural nucleosides have been explored to expand the properties and the applications of oligonucleotides. This paper briefly summarizes nucleic acid analogs in which the base is modified or replaced by an unnatural stacking group for the study of ...
Shu-ichi Nakano, Masayuki Fujii, Naoki Sugimoto   +2 more
doaj   +1 more source