Results 41 to 50 of about 92,583 (117)

Rapid In-Vitro Inactivation of Various SARS-CoV-2 Strains Using Ionizing Radiation: New Inactivation Patterns and Mechanistic Insights

Engineering
Ionizing radiation presents an important solution for virus inactivation. However, its efficacy for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inactivation and the underlying mechanisms remain unclear.
Wei Wang, Xiaodi Zhang, Jiageng Yu, Tianhao Weng, Zhiyang Yu, Zhigang Wu, Danrong Shi, Sufen Zhang, Xiangyun Lu, Osama Alam, Dahang Shen, Qian Bao, Qingfu Ye, Lanjuan Li, Hangping Yao   +14 more
doaj   +1 more source

An epimer of threose nucleic acid enhances oligonucleotide exonuclease resistance through end capping

Communications Chemistry
End capping of oligonucleotides by modified nucleotides is essential for boosting resistance to 3’ exonuclease degradation, thereby enhancing their stability and therapeutic efficacy in vivo.
Junlin Wen, Chunlei Zhang, Xue Chen, Ziwen Dai, Mengting Li, Wenjian Ma, ChiYung Yam, Xiaoluo Huang, Chenghe Xiong, Hui Mei   +9 more
doaj   +1 more source

pH-Control in Aptamer-Based Diagnostics, Therapeutics, and Analytical Applications

Pharmaceuticals, 2018
Aptamer binding has been used effectively for diagnostics, in-vivo targeting of therapeutics, and the construction and control of nanomachines. Nanostructures that respond to pH by releasing or changing affinity to a target have also been used for in ...
Micaela Belleperche, Maria C. DeRosa
doaj   +1 more source

Free-energy simulations reveal molecular mechanism for functional switch of a DNA helicase

eLife, 2018
Helicases play key roles in genome maintenance, yet it remains elusive how these enzymes change conformations and how transitions between different conformational states regulate nucleic acid reshaping.
Wen Ma, Kevin D Whitley, Yann R Chemla, Zaida Luthey-Schulten, Klaus Schulten   +4 more
doaj   +1 more source

Synchrotron-radiation vacuum-ultraviolet circular dichroism spectroscopy in structural biology: an overview

Biophysics and Physicobiology, 2019
Circular dichroism spectroscopy is widely used for analyzing the structures of chiral molecules, including biomolecules. Vacuum-ultraviolet circular dichroism (VUVCD) spectroscopy using synchrotron radiation can extend the short-wavelength limit into the
Kunihiko Gekko
doaj   +1 more source

Nucleic Acid Conformation Influences Postsynthetic Suzuki-Miyaura Labeling of Oligonucleotides. [PDF]

Bioconjug Chem, 2020
Walunj MB, Srivatsan SG.
europepmc   +1 more source

Nucleic acid stain-dependent single strand conformation polymorphisms

BioTechniques, 2004
David R. McKee, M. Scott Thomson
doaj   +1 more source

Buffer optimization of siRNA-lipid nanoparticles mitigates lipid oxidation and RNA-lipid adduct formation

Nature Communications
Lipid nanoparticles are a versatile class of clinically approved drug delivery vehicles, particularly for nucleic acid cargoes. Despite this, these materials often suffer from instability issues that limit shelf-life or necessitate storage at ultra-cold ...
Daniel A. Estabrook, Lihua Huang, Olivia R. Lucchese, Dylan J. Charland, Zhao Yu, Fareed Bhasha Sayyed, Jonas Y. Buser, Younghoon Oh, Xingyan Liu, Harmon A. Johnson, Kenneth G. Rodriguez, Noah A. Wambolt, Sonia A. Corba, Geoffrey T. Nash, Dennis Yang, Tingting Wang   +15 more
doaj   +1 more source

Protein-DNA complexation: contact profiles in DNA grooves

Біофізичний вісник, 2017
Background: Investigation of the specific protein-DNA complexation mechanisms allows to establish general principles of molecular recognition, which must be taken into account while developing artificial nanostructures based on DNA, and to improve the ...
M. Yu. Zhitnikova, A. V. Shestopalova
doaj  

Mesoscopic irreversible thermodynamics of aging kinetics of alpha polypeptides [DNA] under various constraints: Special reference to the simple spring mechanics

AIP Advances
The mesoscopic irreversible thermodynamic treatment of α-polypeptides and the helical polynucleotides (DNA) furnishes two sets of analytical expressions, which allow us not only to analyze the reversible force–extension experiments performed by atomic ...
Tarik Omer Ogurtani
doaj   +1 more source