Results 41 to 50 of about 195,029 (299)
Quantitative Trait Loci for Murine Growth [PDF]
Abstract Body size is an archetypal quantitative trait with variation due to the segregation of many gene loci, each of relatively minor effect, and the environment. We examine the effects of quantitative trait loci (QTLs) on age-specific body weights and growth in the F2 intercross of the LG/J and SM/J strains of inbred mice.
Cheverud J.M. +5 more
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Genetic regulation of cholesterol absorption and plasma plant sterol levels
The molecular basis of the processes that control two closely related traits, the absorption of cholesterol from the intestines and plasma plant sterol levels, are only partially understood. The discovery that mutations in two novel hemitransporters, ATP
Ephraim Sehayek
doaj +1 more source
Quantitative trait Loci for health traits in Finnish Ayrshire cattle [PDF]
A whole-genome scan was conducted to search for quantitative trait loci (QTL) affecting health traits in Finnish Ayrshire dairy cattle. The mapping population consisted of 12 bulls and their 491 sons in a granddaughter design. A total of 150 markers were
de Koning, D J +5 more
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Root architectural traits are governed by many genes exhibiting polygenic inheritance. The dissection of the genetic basis of root traits could be achieved by mapping of quantitative trait loci (QTLs) using molecular markers.
D. R. Gimhani +3 more
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Mapping quantitative trait loci underlying triploid endosperm traits [PDF]
Endosperm, which is derived from two polar nuclei fusing with one sperm, is a triploid tissue in cereals. Endosperm tissue determines the grain quality of cereals. Improving grain quality is one of the important breeding objectives in cereals. However, current statistical methods for mapping quantitative trait loci (QTL) under diploid genetic control ...
C, Xu, X, He, S, Xu
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Summary: We designed a massively parallel reporter assay (MPRA) in an Epstein-Barr virus transformed B cell line to directly characterize the potential for histone post-translational modifications, i.e., histone quantitative trait loci (hQTLs ...
Yao Fu +8 more
doaj +1 more source
Integration of QTL and bioinformatic tools to identify candidate genes for triglycerides in mice
To identify genetic loci influencing lipid levels, we performed quantitative trait loci (QTL) analysis between inbred mouse strains MRL/MpJ and SM/J, measuring triglyceride levels at 8 weeks of age in F2 mice fed a chow diet.
Magalie S. Leduc +6 more
doaj +1 more source
Linkage disequilibrium interval mapping of quantitative trait loci
Background For many years gene mapping studies have been performed through linkage analyses based on pedigree data. Recently, linkage disequilibrium methods based on unrelated individuals have been advocated as powerful tools to refine estimates of gene ...
de Rochambeau Hubert +4 more
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An enormous challenge in the post-genome era is to annotate and resolve the consequences of genetic variation on diverse phenotypes. The genome-wide association study (GWAS) is a well-known method to identify potential genetic loci for complex traits ...
Kai Yuan +7 more
doaj +1 more source
Adaptive evolution of molecular phenotypes
Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under
Armita Nourmohammad +13 more
core +1 more source

