Structure of transcribing RNA polymerase II-nucleosome complex
Nature Communications, 2018 Eukaryotic transcription requires passage of RNA polymerase II (Pol II) through chromatin, which is impaired by nucleosomes. Here the authors report the cryo-EM structure of transcribing Pol II engaged with a downstream nucleosome core particle at an ...
Lucas Farnung +2 more
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BMC Evolutionary Biology, 2004 Background The primate-specific Alu elements, which originated 65 million years ago, exist in over a million copies in the human genome. These elements have been involved in genome shuffling and various diseases not only through retrotransposition but ...
Brahmachari Samir K +3 more
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A global function for transcription factors in assisting RNA polymerase II termination. [PDF]
, 2017 The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized.
Chanfreau, Guillaume F, Roy, Kevin
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Effect of CFIm68 knockdown on RNA polymerase II transcription
BMC Research Notes, 2019 Objectives Transcription of eukaryotic protein-coding genes by RNA polymerase II (pol II) is highly regulated at initiation, elongation and termination.
Michael Tellier +3 more
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A two-state model for the dynamics of the pyrophosphate ion release in bacterial RNA polymerase. [PDF]
PLoS Computational Biology, 2013 The dynamics of the PPi release during the transcription elongation of bacterial RNA polymerase and its effects on the Trigger Loop (TL) opening motion are still elusive.
Lin-Tai Da +3 more
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Transcription-associated breaks in Xeroderma Pigmentosum group D cells from patients with combined features of Xeroderma Pigmentosum and Cockayne Syndrome [PDF]
, 2005 Defects in the XPD gene can result in several clinical phenotypes, including xeroderma pigmentosum (XP), trichothiodystrophy, and, less frequently, the combined phenotype of XP and Cockayne syndrome (XP-D/CS).
Andressoo, Jaan-Olle +12 more
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RNA Polymerase II CTD phosphatase Rtr1 fine-tunes transcription termination.
PLoS Genetics, 2020 RNA Polymerase II (RNAPII) transcription termination is regulated by the phosphorylation status of the C-terminal domain (CTD). The phosphatase Rtr1 has been shown to regulate serine 5 phosphorylation on the CTD; however, its role in the regulation of ...
Jose F Victorino +10 more
doaj +1 more source
Impact of template backbone heterogeneity on RNA polymerase II transcription. [PDF]
, 2014 Variations in the sugar component (ribose or deoxyribose) and the nature of the phosphodiester linkage (3'-5' or 2'-5' orientation) have been a challenge for genetic information transfer from the very beginning of evolution.
Chong, Jenny +5 more
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Estrogen-induced modification of uterine RNA polymerase activity depends on localization of the estrogen receptor [PDF]
Archives of Biological Sciences, 2007 The aim of this study was to examine the effects of estradiol (E2) on activity of RNA polymerase I and RNA polymerase II in uterine nuclei of ovariectomized (OVX) female rats.
Žakula Zorica +5 more
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RNA elements directing in vivo assembly of the 7SK/MePCE/Larp7 transcriptional regulatory snRNP [PDF]
, 2013 Through controlling the nuclear level of active positive transcription elongation factor b (P-TEFb), the 7SK small nuclear RNA (snRNA) functions as a key regulator of RNA polymerase II transcription.
Bayfield +43 more
core +2 more sources