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Radioimmunotherapy of fungal diseases: the therapeutic potential of cytocidal radiation delivered by antibody targeting fungal cell surface antigens [PDF]
Frontiers in Microbiology, 2012 Radioimmunotherapy is the targeted delivery of cytocidal radiation to cells via specific antibody. Although mature for the treatment of cancer, RIT of infectious diseases is in pre-clinical development. However, as there is an obvious and urgent need for
Joshua D Nosanchuk, Ekaterina eDadachova
doaj +5 more sources
Vaccines for human fungal diseases: close but still a long way to go
npj Vaccines, 2021 Despite the substantial global burden of human fungal infections, there are no approved fungal vaccines to protect at risk individuals. Here, we review the progress that has been made and the challenges that lie ahead in the quest towards efficacious ...
Lorena V. N. Oliveira +3 more
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Galactofuranose antigens, a target for diagnosis of fungal infections in humans [PDF]
Future Science OA, 2017 The use of biomarkers for the detection of fungal infections is of interest to complement histopathological and culture methods. Since the production of antibodies in immunocompromised patients is scarce, detection of a specific antigen could be ...
C. Marino +2 more
semanticscholar +4 more sources
Antibodies targeting Candida albicans Als3 and Hyr1 antigens protect neonatal mice from candidiasis
Frontiers in Immunology, 2022 Pre-term infants in neonatal intensive care units are vulnerable to fungal sepsis. In this patient population, Candida albicans remains the predominant fungal pathogen causing high morbidity and mortality, despite antifungal therapy.
Shakti Singh +6 more
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Fungal Antigens Expressed during Invasive Aspergillosis [PDF]
Infection and Immunity, 2005 ABSTRACTRabbits that had been infected intravenously with conidiospores ofAspergillus fumigatuswere used as sources of antibody for screening a λ phage cDNA expression library. The cDNA was derived fromA. fumigatusmRNA that had been extracted from newly formed, germling hyphae. Thirty-six antigens were identified using antisera from six rabbits. Though
Nicole Denikus +5 more
semanticscholar +5 more sources
The Role of B-Cells and Antibodies against Candida Vaccine Antigens in Invasive Candidiasis
Vaccines, 2021 Systemic candidiasis is an invasive fungal infection caused by members of the genus Candida. The recent emergence of antifungal drug resistance and increased incidences of infections caused by non-albicans Candida species merit the need for developing ...
Manisha Shukla +2 more
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Toward Developing a Universal Treatment for Fungal Disease Using Radioimmunotherapy Targeting Common Fungal Antigens [PDF]
Mycopathologia, 2012 Previously, we demonstrated the ability of radiolabeled antibodies recognizing the cryptococcal polysaccharide capsule to kill Cryptococcus neoformans both in vitro and in infected mice. This approach, known as radioimmunotherapy (RIT), uses the exquisite ability of antibodies to bind antigens to deliver microbicidal radiation.
R. Bryan +12 more
semanticscholar +4 more sources
PLoS ONE, 2012 Mortality associated with invasive aspergillosis (IA) remains high, partly because of delayed diagnosis. Detection of microbial exoantigens, released in serum and other body fluids during infection, may help timely diagnosis. In course of IA, Aspergillus
Simon F Dufresne +7 more
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Monocytes and the Host Response to Fungal Pathogens
Frontiers in Cellular and Infection Microbiology, 2020 Monocytes and their derivatives, including macrophages and dendritic cells, play diverse roles in the response to fungal pathogens. Sensing of fungi by monocytes triggers signaling pathways that mediate direct effects like phagocytosis and cytokine ...
Lena J. Heung
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Frontiers in Immunology, 2017 The NLRP3 inflammasome is activated in response to different bacterial, viral, and fungal pathogens and serves as modulator of different pattern recognition receptors signaling pathways.
Mohamed F. Ali +3 more
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