Results 1 to 10 of about 2,013 (172)

Biomimetic chemistry of hemeproteins.

The Keio Journal of Medicine, 1989
Hemeproteins play important physiological roles for an oxygen metabolism in living organisms. Their functions are divided to three main groups, i) hemoglobins, myoglobins and the cytochromes which function by transporting and storing dioxygen and electrons; ii) catalase and peroxidases which are activated by hydrogen peroxide, iii) cytochrome oxidase ...
David Dolphin
openaire   +5 more sources

Mechanistics of pH-Dependent Sulfmyoglobin Formation: Spin Control and His64 Proton Relay

Journal of Chemistry
The chemistry of hydrogen sulfide (H2S) has been directed towards physiologically relevant hemeproteins, including myoglobin, hemoglobin, and other similar proteins.
Angel D. Rodriguez-Mackenzie, Lysmarie Santos-Velazquez, Héctor D. Arbelo-Lopez, Troy Wymore, Juan Lopez-Garriga   +4 more
doaj   +2 more sources

Demonstration that spleen green hemeprotein is identical to granulocyte myeloperoxidase

Journal of Biological Chemistry, 1989
The biochemical, spectroscopic, enzymatic, and redox properties of spleen myeloperoxidase, a peroxidase formerly called "spleen green hemeprotein," and granulocyte myeloperoxidase were compared by electrophoresis, amino-terminal amino acid sequences, optical and EPR spectroscopy, steady-state enzyme kinetics, and oxidation-reduction potential.
R C Prince, Henry H.C. Lee, Masao Ikeda-Saito, S Kimura, H S Eck, K S Booth, Kazuhiko Adachi, W S Caughey   +7 more
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Role of the Circadian Gas-Responsive Hemeprotein NPAS2 in Physiology and Pathology

Biology, 2023
Neuronal PAS domain protein 2 (NPAS2) is a hemeprotein comprising a basic helix–loop–helix domain (bHLH) and two heme-binding sites, the PAS-A and PAS-B domains. This protein acts as a pyridine nucleotide-dependent and gas-responsive CO-dependent transcription factor and is encoded by a gene whose expression fluctuates with circadian rhythmicity. NPAS2
Emanuele Murgo, Tommaso Colangelo, Maria Marina Bellet, Francesco Malatesta, Gianluigi Mazzoccoli   +4 more
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Heme on innate immunity and inflammation

Frontiers in Pharmacology, 2014
Heme is an essential molecule expressed ubiquitously all through our tissues. Heme plays major functions in cellular physiology and metabolism as the prostetic group of diverse proteins.
Fabianno Ferreira Dutra, Marcelo Torres Bozza   +1 more
doaj   +1 more source

Hydrogen sulfide activation in hemeproteins: The sulfheme scenario [PDF]

Journal of Inorganic Biochemistry, 2014
Traditionally known as a toxic gas, hydrogen sulfide (H2S) is now recognized as an important biological molecule involved in numerous physiological functions. Like nitric oxide (NO) and carbon monoxide (CO), H2S is produced endogenously in tissues and cells and can modulate biological processes by acting on target proteins.
Juan López-Garriga, Bessie B. Ríos-González, Elddie M. Roman-Morales, Ruth Pietri   +3 more
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Genome-wide structural and evolutionary analysis of the P450 monooxygenase genes (P450ome) in the white rot fungus Phanerochaete chrysosporium : Evidence for gene duplications and extensive gene clustering

BMC Genomics, 2005
Background Phanerochaete chrysosporium, the model white rot basidiomycetous fungus, has the extraordinary ability to mineralize (to CO2) lignin and detoxify a variety of chemical pollutants.
Yadav Jagjit S, Chakraborty Ranajit, Doddapaneni Harshavardhan   +2 more
doaj   +1 more source

Nitric Oxide Binding Geometry in Heme-Proteins: Relevance for Signal Transduction

Antioxidants
Nitric oxide (NO) synthesis, signaling, and scavenging is associated to relevant physiological and pathological events. In all tissues and organs, NO levels and related functions are regulated at different levels, with heme proteins playing pivotal roles.
Giovanna De Simone, Alessandra di Masi, Diego Sbardella, Paolo Ascenzi, Massimiliano Coletta   +4 more
doaj   +1 more source

Influence of the freezing process upon fluoride binding to hemeproteins [PDF]

Biophysical Journal, 1991
Fluoride association with ferric myoglobins and hemoglobins in aqueous buffers above freezing has been well studied. We chose this reaction to investigate the feasibility of observing titration intermediates and estimating dissociation constants at the freezing temperature by electron paramagnetic resonance spectroscopy at cryogenic temperatures ...
An-Suei Yang, Arthur S. Brill
openaire   +2 more sources

Genetic Polymorphisms in CYP2 Gene Family in Bulgarian Individuals and their Clinical Implications

Acta Medica Bulgarica
The cytochrome P450 superfamily consists of hemeproteins involved in the detoxication of different xenobiotics, including drugs. The CYP2 gene family is responsible for the metabolism of 80% of the drugs in clinical use.
Yovinska S., Bakalov D., Mihova K., Kamenarova K., Kaneva R., Nikolov R., Dimova I.   +6 more
doaj   +1 more source