Results 1 to 10 of about 784,891 (338)
Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a)
Pharmaceuticals, 2023 Dyslipidemia treatment is of major importance in reducing the risk of atherosclerotic cardiovascular disease (ASCVD), which is still the most common cause of death worldwide. During the last decade, a novel lipid-lowering drug category has emerged, i.e., proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. Apart from the two available anti-
Niki Katsiki +3 more
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HDL and plaque regression in a multiphase model of early atherosclerosis [PDF]
, 2023 Atherosclerotic plaques are accumulations of cholesterol-engorged macrophages in the artery wall. Plaque growth is initiated and sustained by the deposition of low density lipoproteins (LDL) in the artery wall. High density lipoproteins (HDL) counterbalance the effects of LDL by accepting cholesterol from macrophages and removing it from the plaque. In
arxiv +1 more source
Oxidized Low-Density Lipoprotein [PDF]
, 2009 Oxidized low-density lipoprotein (Ox-LDL) has been studied for over 25 years. Numerous pro- and anti-atherogenic properties have been attributed to Ox-LDL. Yet, Ox-LDL has neither been defined nor characterized, as its components and composition change depending on its source, method of preparation, storage, and use. It contains unoxidized and oxidized
Nalini Santanam +3 more
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Low-Density Lipoproteins Oxidation and Endometriosis [PDF]
Mediators of Inflammation, 2013 The etiopathogenesis of endometriosis still remains unknown. Recent data provide new valuable information concerning the role of oxidative stress in the pathophysiology of the disease. It has been proved that levels of different lipid peroxidation end products are increased in both peritoneal fluid (PF) and serum of endometriotic patients.
Jan Kotarski +6 more
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Low density lipoproteins in atherosclerosis.
Journal of Lipid Research, 1988 Low density lipoproteins (LDL) have long been implicated in the development of atherosclerosis. Perhaps the most convincing evidence that these lipoproteins are causative factors in this disease is the genetic disorder, familial hypercholesterolemia, in which homozygous patients develop massive LDL concentrations and frequently die within the second ...
John S. Parks +3 more
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A comparative study of the lipid panel levels at different duration time and temperature storage [PDF]
arXiv, 2023 Background: the stability of serum specimen during time storage is importance in clinical and medical science researches in addition of diagnosis. Lipids are organic molecules that classified into 8 classes: fatty acids, phospholipids, glycerolipids, saccharolipids, polyketides, prenol lipids, sterol, and sphingolipids.
arxiv
Low density lipoprotein oxidation in children [PDF]
Reproduction Nutrition Development, 1998 N.A.
IUGHETTI, Lorenzo +4 more
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Low-Density Lipoprotein Receptors
, 1991 The origins of the receptor theory are based on the work of Paul Ehrlich (1854–1915) and John Newport Langley (1852–1925) (Parascandola 1981), who were the first to postulate that specific cellular reactions to drugs must be based on so-called receptive substances.
Niendorf, A. +2 more
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Low density lipoprotein misfolding and amyloidogenesis
The FASEB Journal, 2008 In early atherogenesis, subendothelial retention of lipidic droplets is associated with an inflammatory response-to-injury, culminating in the formation of foam cells and plaque. Low density lipoprotein (LDL) is the main constituent of subendothelial lipidic droplets. The process is believed to occur following LDL modification. Searching for a modified
Parasassi, T. +11 more
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Non-oxidative modification of native low-density lipoprotein by oxidized low-density lipoprotein [PDF]
Biochemical Journal, 1996 The oxidative modification of low-density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis, although little is known as yet about the precise mechanism of oxidation in vivo. The studies presented here demonstrate that, in the absence of cells or transition metals, oxidized LDL can modify native LDL through co-incubation in ...
David S. Leake +2 more
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