Results 1 to 10 of about 58,180 (169)

Approaches to Visualising Endocytosis of LDL-Related Lipoproteins [PDF]

Biomolecules, 2022
Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated endocytosis to the less selective and actin-driven macropinocytosis.
Halima Siddiqui, Nikita Yevstigneyev, Golnoush Madani, Sally McCormick   +3 more
openaire   +3 more sources

Native and oxidised lipoproteins negatively regulate the serum amyloid A‐induced NLRP3 inflammasome activation in human macrophages

Clinical & Translational Immunology, 2021
Objectives The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators ...
Katariina Nurmi, Katri Niemi, Ilona Kareinen, Kristiina Silventoinen, Martina B Lorey, Yan Chen, Vesa‐Petteri Kouri, Jukka Parantainen, Timo Juutilainen, Katariina Öörni, Petri T Kovanen, Dan Nordström, Sampsa Matikainen, Kari K Eklund   +13 more
doaj   +1 more source

Lipoprotein lipase-facilitated uptake of LDL is mediated by the LDL receptor [PDF]

Journal of Lipid Research, 2007
LPL mediates the uptake of lipoproteins into different cell types independent of its catalytic activity. The mechanism of this process and its physiological relevance are not clear. Taking into account the importance of the endothelial barrier for lipoprotein uptake, in vitro studies with primary aortic endothelial cells from wild-type and low density ...
Britta Loeffler, Joerg Heeren, Mareike Blaeser, Herbert Radner, Daniel Kayser, Birol Aydin, Martin Merkel   +6 more
openaire   +3 more sources

Roles of peripheral lipoproteins and cholesteryl ester transfer protein in the vascular contributions to cognitive impairment and dementia

Molecular Neurodegeneration, 2023
This narrative review focuses on the role of cholesteryl ester transfer protein (CETP) and peripheral lipoproteins in the vascular contributions to cognitive impairment and dementia (VCID).
Tetiana Poliakova, Cheryl L. Wellington
doaj   +1 more source

Protein S on the surface of plasma lipoproteins: a potential mechanism for protein S delivery to the atherosclerotic plaques?

Bleeding, Thrombosis and Vascular Biology, 2022
The anticoagulant protein S (PS) binds phospholipids with very high affinity, but PS interaction with lipoproteins and lipidrich atherosclerotic plaques remains still poorly defined.
Marcello Baroni, Paolo Ferraresi, Nicole Ziliotto, Daria Bortolotti, Pierfilippo Acciarri, Nicola Martinelli, Giovanna Marchetti, Matteo Coen, Francesco Bernardi   +8 more
doaj   +1 more source

Molecular and Cellular Mechanisms of Electronegative Lipoproteins in Cardiovascular Diseases

Biomedicines, 2020
Dysregulation of glucose and lipid metabolism increases plasma levels of lipoproteins and triglycerides, resulting in vascular endothelial damage. Remarkably, the oxidation of lipid and lipoprotein particles generates electronegative lipoproteins that ...
Liang-Yin Ke, Shi Hui Law, Vineet Kumar Mishra, Farzana Parveen, Hua-Chen Chan, Ye-Hsu Lu, Chih-Sheng Chu   +6 more
doaj   +1 more source

Atherosclerosis Calcification: Focus on Lipoproteins

Metabolites, 2023
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of lipids in the vessel wall, leading to the formation of an atheroma and eventually to the development of vascular calcification (VC).
Jaap G. Neels, Georges Leftheriotis, Giulia Chinetti   +2 more
doaj   +1 more source

Lipoprotein metabolism in the suckling rat: characterization of plasma and lymphatic lipoproteins.

Journal of Lipid Research, 1983
Suckling rat plasma contains (in mg/dl): chylomicrons (85 +/- 12); VLDL (50 +/- 6); LDL (200 +/- 23); HDL1 (125 +/- 20); and HDL2 (220 +/- 10), while lymph contains (in mg/dl): chylomicrons (9650 +/- 850) and VLDL (4570 +/- 435) and smaller amounts of ...
G J Fernando-Warnakulasuriya, M L Eckerson, W A Clark, M A Wells   +3 more
doaj   +1 more source

Increased fluidity and oxidation of malarial lipoproteins: relation with severity and induction of endothelial expression of adhesion molecules

Lipids in Health and Disease, 2004
Introduction Oxidative stress has been demonstrated in malaria. The potential oxidative modification of lipoproteins derived from malaria patients was studied. These oxidized lipids may have role in pathogenesis of malaria.
Looareesuwan Sornchai, Brittenham Gary, Leowattana Wattana, Krudsood Srivicha, Yamanont Paveena, Sibmooh Nathawut, Udomsangpetch Rachanee   +6 more
doaj   +1 more source

Lipoproteins of the extravascular space: alterations in low density lipoproteins of interstitial inflammatory fluid

Journal of Lipid Research, 1983
Although extrahepatic degradation of low density lipoproteins (LDL) by peripheral cells is considered to be a significant component of daily cholesterol homeostasis, the nature of lipoproteins in the extravascular space has not been well described. Using
T L Raymond, S A Reynolds
doaj   +1 more source