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2022 Consensus Statement on the Management of Familial Hypercholesterolemia in Korea [PDF]
Journal of Lipid and Atherosclerosis, 2022 Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical.
Chan Joo Lee +7 more
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Research in Cardiovascular Medicine, 2022 Background: Familial hypercholesterolemia (FH) is an inherited disorder characterized by significantly elevated levels of low-density lipoprotein (LDL) cholesterol and is usually diagnosed after the occurrence of major adverse cardiovascular event.
Edin Begic +17 more
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Role of PCSK9 Inhibitors in Patients with Familial Hypercholesterolemia [PDF]
Endocrinology and Metabolism, 2021 Patients with familial hypercholesterolemia (FH) are at high or very high risk for cardiovascular disease. Those with heterozygous FH (HeFH) often do not reach low-density lipoprotein cholesterol (LDL-C) targets with statin and ezetimibe therapy, and ...
Brian Tomlinson +3 more
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Individualized Treatment for Patients With Familial Hypercholesterolemia
Journal of Lipid and Atherosclerosis, 2022 Familial hypercholesterolemia (FH) is one of the most common and, therefore, important inherited disorders in preventive cardiology. This disease is mainly caused by a single pathogenic mutation in the low-density lipoprotein receptor or its associated ...
Hayato Tada +2 more
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Molecular diagnosis methods in familial hypercholesterolemia
Anatolian Journal of Cardiology, 2020 Familial hypercholesterolemia (FH) is considered the genetic cause of coronary heart disease and ischemic stroke. FH is mainly an autosomal codominant pattern-based disorder and is primarily determined by point mutations within the low-density ...
Valeriu Moldovan +2 more
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Interaction between Glucose and Lipid Metabolism: More than Diabetic Dyslipidemia [PDF]
Diabetes & Metabolism Journal, 2015 Glucose and lipid metabolism are linked to each other in many ways. The most important clinical manifestation of this interaction is diabetic dyslipidemia, characterized by elevated triglycerides, low high density lipoprotein cholesterol (HDL-C), and ...
Klaus G. Parhofer
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Journal of Lipid and Atherosclerosis, 2022 Objective The aim of the current study was to investigate whether the impact of low-density lipoprotein-cholesterol (LDL-C) levels on cardiovascular risk is different between individuals with severe hypercholesterolemia and diabetes mellitus (DM) and ...
Chan Joo Lee +3 more
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Journal of Lipid Research, 1982 Cholesteryl ester-rich beta-very low density lipoproteins (beta-VLDL) are beta-migrating lipoproteins that accumulate in the d < 1.006 g/ml fraction of plasma from cholesterol-fed animals and from patients with Type III hyperlipoproteinemia.
M Fainaru +3 more
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Role of apolipoproteins E and C in type V hyperlipoproteinemia.
Journal of Lipid Research, 1988 Type V hyperlipoproteinemia is characterized by elevations of chylomicron (CM) and very low density lipoprotein (VLDL) triglycerides. The development of this lipid disorder involves a multitude of metabolic derangements including deficient clearance of ...
T Kuusi +3 more
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Update on Familial Hypercholesterolemia: Diagnosis, Cardiovascular Risk, and Novel Therapeutics [PDF]
Endocrinology and Metabolism, 2017 In recent studies, the reported prevalence of heterozygous familial hypercholesterolemia (FH) has been higher than in previous reports. Although cascade genetic screening is a good option for efficient identification of affected patients, diagnosis using
Sang-Hak Lee
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