Results 41 to 50 of about 11,928,997 (202)

Alteration in oral and non‐oral tissues in ligature‐induced periodontitis mice with the Alzheimer's disease risk factor APOE4

European Journal of Oral Sciences, Volume 134, Issue 4, August 2026.
Abstract The APOE4 gene, particularly the ε4 allele, is linked to susceptibility to Alzheimer's disease, and periodontitis can cause pathological changes in multiple organs, but combined effects of these conditions and the impact of tumor necrosis factor (TNF)‐α regulation on the combined effects remain unclear.
Ae Ri Kim, Yun‐Jung Yoo, Eun‐Jung Bak   +2 more
wiley   +1 more source

How does type 2 diabetes modify the risk of Alzheimer's disease?

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland, A. Chen, H‐T. Nguyen‐Hao, H. Mundell, E. Aladyeva, M. J. Hofer, O. Harari, S. M. Twigg   +7 more
wiley   +1 more source

Clinical and Molecular Genetic Risk Factors for Severe Familial Hypercholesterolemia

Journal of Lipid and Atherosclerosis
Objective Familial hypercholesterolemia (FH) is an autosomal dominant disorder associated with a markedly elevated, yet heterogeneous, risk of atherosclerotic cardiovascular disease (ASCVD).
Eun Hoo Rho, Yura Kang, Minjae Yoon, Nak-Hoon Son, Sung Hee Choi, Sang-Hak Lee, Kyong Soo Park, Soo Heon Kwak, n behalf of the Korean Familial Hypercholesterolemia (KFH) Registry Investigators   +8 more
doaj   +1 more source

Recurrent Pancreatitis Induced by Uncontrolled Type V Hyperlipoproteinemia

, 2019
Background: Type V Hyperlipoproteinemia is a rare disease characterized by increased chylomicron and very low-density lipoprotein (VLDL) plasma levels. No official guidelines for treatment or monitoring of this disorder have been established due to the ...
Perez, Laura Oben, Rivero, Bianshly Rivera, Pla, Carlos, Weare-Regales, Natalia   +3 more
core   +1 more source

Quantitation of human apolipoprotein C-III and its subspecie by radioimmunoassay and analytical isoelectric focusing: abnormal plasma triglyceride-rich lipoprotein apolipoprotein C-III subspecie concentrations in hypertriglyceridemia.

Journal of Lipid Research, 1981
A specific, accurate, and sensitive double antibody radioimmunoassay for measuring human apolipoprotein (apo) C-III has been developed. Anti-apoC-III(1) developed in rabbits cross-reacted completely with apoC-III subspecies.
M L Kashyap, L S Srivastava, B A Hynd, P S Gartside, G Perisutti   +4 more
doaj   +1 more source

HYPERLIPOPROTEINEMIA IN PATIENTS WITH CHRONIC RENAL FAILURE

, 1972
Concentrations of triglycerides and cholesterol in serum and the distribution of plasma lipoprotein fractions have been studied in 25 patients with chronic non‐nephrotic renal failure.
Brøns, Morten, Hørder, Mogens, Christensen, N. C.   +2 more
core   +1 more source

A Novel APOC2 Mutation in a Colombian Patient with Recurrent Hypertriglyceridemic Pancreatitis

The Application of Clinical Genetics, 2020
Gabriel D Pinilla-Monsalve,1,* Juliana Lores,1,2,* Harry Pachajoa,1,2 Juan D López-Ponce de León,1,3 Alejandro López,1,4 Lisa X Rodríguez-Rojas,1,2 José A Nastasi-Catanese1,2 1Faculty of Health Sciences, Universidad ...
Pinilla-Monsalve GD, Lores J, Pachajoa H, López-Ponce de León JD, López A, Rodríguez-Rojas LX, Nastasi-Catanese JA   +6 more
doaj  

Inference About Separable Causal Effects With Longitudinal Bivariate Ordinal Responses With Missingness and Censoring

Statistics in Medicine, Volume 45, Issue 3-5, February 2026.
ABSTRACT Causal inference has gained extensive attention in various fields, including healthcare, epidemiology, and social sciences. While many methods have been developed, most research has been directed to handle data with a univariate response variable.
Pingbo Hu, Grace Y. Yi
wiley   +1 more source

Graded Calorie Restriction Causes Graded Slowing of Epigenetic Ageing in Mice

Aging Cell, Volume 25, Issue 1, January 2026.
Graded calorie restriction in male mice modified epigenetic signatures of the liver and slowed ageing rate in a graded manner. ABSTRACT DNA methylation variation is associated with chronological ageing. Calorie restriction (CR) prolongs lifespan and healthspan in many species.
Timothy P. Moulds, Sharon E. Mitchell, Xiaojing Yang, Wei Guo, Emily Chen, Peter D. Adams, John R. Speakman   +6 more
wiley   +1 more source

Cellular Senescence, Inflammaging and Cardiovascular Disease

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Aging is the most important yet unmodifiable risk factor for cardiovascular disease (CVD). As a result, targeting cardiovascular aging has emerged as a promising strategy to promote long‐term cardiovascular health. This review summarizes current knowledge on the effects of aging within the cardiovascular system as well as systemic processes ...
Lukas Zanders, Denada Arifaj, Julian U. G. Wagner, Stefanie Dimmeler   +3 more
wiley   +1 more source