Results 21 to 30 of about 772,552 (212)

Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia

Journal of Lipid Research, 1975
In skin fibroblasts grown from four children with a homozygous form of type II hyperlipoproteinemia, the feedback control of sterol synthesis and the inhibitory effect on hydroxymethylglutaryl (HMG) CoA reductase activity by serum or low density ...
J. Avigan, S.J. Bhathena, M.E. Schreiner
doaj   +1 more source

Premature development of iliac artery stenosis in asymptomatic type II hyperlipoproteinemia.

, 1984
There is conflicting evidence on the relationship between increased low density lipoprotein (LDL) concentration in Type II hyperlipoproteinemia and premature development of peripheral atherosclerosis of the lower limbs.
M Mancini, A Postiglione, F Faccenda, P Rubba, B De Simone, G Riccardi   +5 more
core   +2 more sources

A case report of palmar xanthoma with xanthomatous neuropathy

SAGE Open Medical Case Reports, 2021
Xanthomas are plaques or nodules consisting of an accumulation of excess lipids, resulting in the formation of foam cells in the skin or tendons. Typically, xanthomas are not accompanied by other symptoms. Here, we report a patient with a presentation of
Hyun Yi Lee, Dae Won Koo, Joong Sun Lee
doaj   +1 more source

Alternative cascade-testing protocols for identifying and managing patients with familial hypercholesterolaemia: systematic reviews, qualitative study and cost-effectiveness analysis

Health Technology Assessment, 2023
Background Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia.
Nadeem Qureshi, Bethan Woods, Rita Neves de Faria, Pedro Saramago Goncalves, Edward Cox, Jo Leonardi-Bee, Laura Condon, Stephen Weng, Ralph K Akyea, Barbara Iyen, Paul Roderick, Steve E Humphries, William Rowlands, Melanie Watson, Kate Haralambos, Ryan Kenny, Dev Datta, Zosia Miedzybrodzka, Christopher Byrne, Joe Kai   +19 more
doaj   +1 more source

Identification of an apoC-II variant (apoC-IIBethesda) in a kindred with apoC-II deficiency and type I hyperlipoproteinemia.

Journal of Lipid Research, 1988
Apolipoprotein (apo) C-II deficiency is characterized by elevated plasma triglycerides, chylomicrons, and very low density lipoproteins, as well as reduced levels of low density and high density lipoproteins.
D L Sprecher, L Taam, R E Gregg, S S Fojo, D M Wilson, M L Kashyap, H B Brewer, Jr   +6 more
doaj   +1 more source

Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes

Journal of Lipid Research, 1999
Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of remnant lipoproteins in the plasma and development of premature atherosclerosis. Although receptor binding-defective forms of apolipoprotein (apo) E are the common
Robert W. Mahley, Yadong Huang, Stanley C. Rall, Jr.   +2 more
doaj   +1 more source

HYPERLIPOPROTEINEMIA IN PATIENTS WITH CHRONIC RENAL FAILURE

, 1972
Concentrations of triglycerides and cholesterol in serum and the distribution of plasma lipoprotein fractions have been studied in 25 patients with chronic non‐nephrotic renal failure.
Brøns, Morten, Hørder, Mogens, Christensen, N. C.   +2 more
core   +1 more source

Hepatic cholesterol metabolism in normo- and hyperlipidemic patients with cholesterol gallstones.

Journal of Lipid Research, 1979
In vivo studies have shown abnormalities in cholesterol and bile acid metabolism in primary hyperlipoproteinemia (HLP). The aim of the present investigation was to determine if the increased production of cholesterol in HLP type IV can be attributed to a
J Ahlberg, B Angelin, I Björkhem, K Einarsson, B Leijd   +4 more
doaj   +1 more source

How does type 2 diabetes modify the risk of Alzheimer's disease?

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland, A. Chen, H‐T. Nguyen‐Hao, H. Mundell, E. Aladyeva, M. J. Hofer, O. Harari, S. M. Twigg   +7 more
wiley   +1 more source

Human type II hyperlipoproteinemia enhances platelet-collagen adhesion in flowing nonanticoagulated blood.

, 1993
We investigated the effects of high plasma lipid levels on platelet adhesion and platelet thrombus formation in nonanticoagulated human blood on collagen fibrils at an arterial wall shear rate of 2600 seconds-1. Nonanticoagulated blood was drawn directly
A Diquélou, J Ferrières, Y Cadroy, P Douste-Blazy, K S Sakariassen, S Lemozy, B Boneu   +6 more
core   +1 more source