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Regulation of NF-κB activity through lysine monomethylation of p65 [PDF]

Proceedings of the National Academy of Sciences, 2009
NF-κB is a key activator of inflammatory and immune responses with important pathological roles in cancer, heart disease, and autoimmune diseases. Transcriptional activity of NF-κB is regulated by different posttranslational modifications. Here, we report a novel mechanism of NF-κB regulation through lysine monomethylation by SET9 methyltransferase ...
Ea, Chee-Kwee, Baltimore, David
openaire   +10 more sources

TLR7, TLR9, MyD88, and NF-κB role on platelet aggregation in Yucatecan patients with type 2 diabetes

Alad, 2022
Objective: To analyze the expression of TLR7, TLR9, and signaling proteins MyD88 and NF-κB, and their relationship with platelet aggregation in Yucatecan patients with type 2 diabetes. Material and methods: Platelet aggregation was determined by light transmission and protein expression by flow cytometry in 31 patients and 29 controls from Yucatan ...
Lucía G. González-Espinosa, Irma G. Quintal-Ortiz, Yumi E. Nakazawa-Ueji, Juan D. Villarreal-Ku, Ligia G. Alonso-Salomón, Isaac A. López-Briceño, Nina Valadez-González, Guillermo Valencia-Pacheco   +7 more
openaire   +2 more sources

Two Pathways to NF-κB [PDF]

Molecular Cell, 2002
NF-kappaB is a transcription factor that is critical for innate and adaptive immunity. Recently, a noncanonical pathway for NF-kappaB activation has emerged. Four recent papers provide physiological roles for this pathway and expand our understanding of lymphoid development and organogenesis with potential applications in the treatment of autoimmune ...
Pomerantz, Joel L., Baltimore, David
openaire   +3 more sources

Regulation of NF-κB by PML and PML-RARα [PDF]

, 2017
Promyelocytic Leukemia (PML) is a nuclear protein that forms sub-nuclear structures termed nuclear bodies associated with transcriptionally active genomic regions. PML is a tumour suppressor and regulator of cell differentiation.
Ahmed, Abrar, Carmody, Ruaidhri J., Chen, Youhai H., Keeshan, Karen, Lindsay, Andrew J., McCaffrey, Mary W., Mitxitorena, Izaskun, Pandolfi, Pier Paolo, Wan, Xiaochun   +8 more
core   +1 more source

NF-κB signaling regulates myelination in the CNS [PDF]

Frontiers in Molecular Neuroscience, 2014
Besides myelination of neuronal axons by oligodendrocytes to facilitate propagation of action potentials, oligodendrocytes also support axon survival and function. A key transcription factor involved in these processes is nuclear factor-κB (NF-κB), a hetero or homodimer of the Rel family of proteins, including p65, c-Rel, RelB, p50, and p52.
Thomas eBlank, Marco ePrinz, Marco ePrinz   +2 more
openaire   +4 more sources

Oscillation dynamics underlie functional switching of NF-κB for B-cell activation. [PDF]

, 2016
Transcription factor nuclear factor kappa B (NF-κB) shows cooperative switch-like activation followed by prolonged oscillatory nuclear translocation in response to extracellular stimuli.
Aihara, Kazuyuki, Behar, Marcelo, Hoffmann, Alexander, Inoue, Kentaro, Okada-Hatakeyama, Mariko, Shinohara, Hisaaki, Tanaka, Gouhei, Yumoto, Noriko   +7 more
core   +1 more source

Hypoxia activates IKK-NF-κB and the immune response in Drosophila melanogaster [PDF]

, 2014
Hypoxia, or low oxygen availability, is an important physiological and pathological stimulus for multicellular organisms. Molecularly, hypoxia activates a transcriptional programme directed at restoration of oxygen homoeostasis and cellular survival.
An, Azad, Bartels, Bonello, Centanin, Culver, Cummins, Cummins, Daniel Bandarra, Dekanty, Fandrey, Fu, Glittenberg, H. Arno Muller, Harhaj, Hetru, Jiang, John Biddlestone, Jono, Kenneth, Kounatidis, Lando, Lavista-Llanos, Liu, Lu, Massoumi, Melvin, Moniz, Perkins, Perkins, Ratcliffe, Rius, Rocha, Romero, Ruland, Scholz, Semenza, Sharon Mudie, Silke, Silverman, Silverman, Sonia Rocha, Sonnenfeld, Tornatore, Tsichritzis, van Uden, van Uden, Walmsley, Xue   +48 more
core   +4 more sources

Neurotropin suppresses inflammatory cytokine expression and cell death through suppression of NF-κB and JNK in hepatocytes. [PDF]

, 2014
Inflammatory response and cell death in hepatocytes are hallmarks of chronic liver disease, and, therefore, can be effective therapeutic targets. Neurotropin® (NTP) is a drug widely used in Japan and China to treat chronic pain.
Liang, Shuang, Liu, Cheng, Masuda, Koichi, Naiki, Mitsuru, Roh, Yoon Seok, Seki, Ekihiro, Zhang, Bi   +6 more
core   +12 more sources

WITHDRAWN: The TLR4/MyD88/NF-κB pathway promotes infl ammation in HPV-related cervical cancer cells

Oncotarget, 2018
// Ninghong Jiang 1,2 , Feng Xie 1,2 , Qisang Guo 1,2 , Limei Chen 1,2 , Fang Chen 1,2 , Luopei Guo 1,2 and Long Sui 1,2 1 Medical center for diagnostics and treatments of cervical disease, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China 2 Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases ...
Ninghong Jiang, Ninghong Jiang, Feng Xie, Feng Xie, Qisang Guo, Qisang Guo, Limei Chen, Limei Chen, Fang Chen, Fang Chen, Luopei Guo, Luopei Guo, Long Sui, Long Sui   +13 more
openaire   +2 more sources

Parthenolide attenuates LPS-induced activation of NF-κB in a time-dependent manner in rat myocardium. [PDF]

, 2012
Parthenolide (PTN), a selective nuclear factor kappa B (NF-κB) inhibitor, has been used extensively to inhibit NF-κB activation. The duration of the inhibitory effect of PTN on NF-κB in vivo remains unclear.
Liu, Chunfeng, Liu, Hong, Liu, Xia, Qiao, Shigang, Wang, Chen, Wu, Xuemei, Xie, Hong   +6 more
core   +1 more source