Results 1 to 10 of about 193,556 (316)

Specific association of TBK1 with the trans-Golgi network following STING stimulation

Cell Structure and Function, 2022
Stimulator of interferon genes (STING) is essential for the type I interferon response induced by microbial DNA or self-DNA leaked from mitochondria/nuclei.
Haruka Kemmoku, Yoshihiko Kuchitsu, Kojiro Mukai, Tomohiko Taguchi   +3 more
doaj   +1 more source

STING Operation at the ER/Golgi Interface

Frontiers in Immunology, 2021
DNA is present in the nucleus and mitochondria of eukaryotic cells. There are, however, certain instances in which DNA emerges in the cytosol. The two major sources of cytosolic DNA are self DNA that is leaked out from the nucleus or mitochondria, and ...
Tomohiko Taguchi, Tomohiko Taguchi, Kojiro Mukai, Eiko Takaya, Ruri Shindo   +4 more
doaj   +1 more source

Protein–Protein Interactions and Quantitative Phosphoproteomic Analysis Reveal Potential Mitochondrial Substrates of Protein Phosphatase 2A-B’ζ Holoenzyme

Plants, 2023
Protein phosphatase 2A (PP2A) is a heterotrimeric conserved serine/threonine phosphatase complex that includes catalytic, scaffolding, and regulatory subunits.
Ahmed Elshobaky, Cathrine Lillo, Kristian Persson Hodén, Amr R. A. Kataya   +3 more
doaj   +1 more source

CDK1 controls CHMP7-dependent nuclear envelope reformation

eLife, 2021
Through membrane sealing and disassembly of spindle microtubules, the Endosomal Sorting Complex Required for Transport-III (ESCRT-III) machinery has emerged as a key player in the regeneration of a sealed nuclear envelope (NE) during mitotic exit, and in
Alberto T Gatta, Yolanda Olmos, Caroline L Stoten, Qu Chen, Peter B Rosenthal, Jeremy G Carlton   +5 more
doaj   +1 more source

Characterisation of a novel cold‐adapted calcium‐activated transglutaminase: implications for medicine and food processing

FEBS Open Bio, 2020
Transglutaminases are a family of enzymes that catalyse the cross‐linking of proteins by forming covalent bonds between lysine and glutamine residues in various polypeptides.
Rebeca Garcia Alvarez, Pralav Karki, Ida Elise Langleite, Ragna‐Johanne Bakksjø, Lutz Andreas Eichacker, Clemens Furnes   +5 more
doaj   +1 more source

Imaging of Endoplasmic Reticulum Ca2+ in the Intact Pituitary Gland of Transgenic Mice Expressing a Low Affinity Ca2+ Indicator

Frontiers in Endocrinology, 2021
The adenohypophysis contains five secretory cell types (somatotrophs, lactotrophs, thyrotrophs, corticotrophs, and gonadotrophs), each secreting a different hormone, and controlled by different hypothalamic releasing hormones (HRHs).
Jonathan Rojo-Ruiz, Paloma Navas-Navarro, Lucía Nuñez, Javier García-Sancho, María Teresa Alonso   +4 more
doaj   +1 more source

Chaperones and Proteostasis: Role in Parkinson’s Disease

Diseases, 2020
Proper folding to attain a defined three-dimensional structure is a prerequisite for the functionality of a protein. Improper folding that eventually leads to formation of protein aggregates is a hallmark of several neurodegenerative disorders.
Neha Joshi, Atchaya Raveendran, Shirisha Nagotu   +2 more
doaj   +1 more source

Fusing the 3’UTR of seed storage protein genes leads to massive recombinant protein accumulation in seeds

Scientific Reports, 2023
The demand for recombinant proteins is rising dramatically, and effective production systems are currently being developed. The production of recombinant proteins in plants is a promising approach due to its low cost and low risk of contamination of the ...
Masatake Kanai, Masaya Sugiyama, Maki Kondo, Kenji Yamada, Mikio Nishimura, Shoji Mano   +5 more
doaj   +1 more source

Lysosome-Targeted Biosensor for the Super-Resolution Imaging of Lysosome–Mitochondrion Interaction

Frontiers in Pharmacology, 2022
Background: The interaction between lysosomes and mitochondria includes not only mitophagy but also mitochondrion–lysosome contact (MLC) that enables the two organelles to exchange materials and information.
Han Wang, Han Wang, Guiqian Fang, Huimin Chen, Maomao Hu, Yajuan Cui, Yajuan Cui, Boyang Wang, Yudong Su, Yu Liu, Bo Dong, Bo Dong, Xintian Shao   +12 more
doaj   +1 more source

The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside

Frontiers in Microbiology, 2020
The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription.
Kristin Grøsvik, Almaz Nigatu Tesfahun, Izaskun Muruzábal-Lecumberri, Gyri Teien Haugland, Ingar Leiros, Peter Ruoff, Jan Terje Kvaløy, Ingeborg Knævelsrud, Hilde Ånensen, Marina Alexeeva, Kousuke Sato, Akira Matsuda, Ingrun Alseth, Arne Klungland, Arne Klungland, Svein Bjelland   +15 more
doaj   +1 more source