Duration of rifampin therapy is a key determinant of improved outcomes in early-onset acute prosthetic joint infection due to Staphylococcus treated with a debridement, antibiotics and implant retention (DAIR): a retrospective multicenter study in France [PDF]
Journal of Bone and Joint Infection, 2020 Introduction: In patients undergoing a « debridement, antibiotics, and implant retention » (DAIR) procedure for acute staphylococcal prosthetic joint infection (PJI), post-operative treatment with rifampin has been associated with a higher probability of
A. Becker +29 more
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Controversy about the Role of Rifampin in Biofilm Infections: Is It Justified?
Antibiotics, 2021 Rifampin is a potent antibiotic against staphylococcal implant-associated infections. In the absence of implants, current data suggest against the use of rifampin combinations.
Nora Renz +2 more
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Stability of Rifampin in Dimethylsulfoxide [PDF]
Applied Microbiology, 1969 Stock solutions of rifampin remain stable in dimethylsulfoxide for at least 8 months.
Alfred G. Karlson, John A. Ulrich
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The Journal of Clinical Investigation, 2022 Tuberculous meningitis (TB meningitis) is the most severe form of tuberculosis (TB), requiring 12 months of multidrug treatment for cure, and is associated with high morbidity and mortality.
Camilo A. Ruiz-Bedoya +15 more
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Rifampin-loaded Mesoporous Silica Nanoparticles Improved Physical and Mechanical Properties and Biological Response of Acrylic Bone Cement [PDF]
Journal of Medical Signals and SensorsBackground: Acrylic bone cement, which is used to fix implants in the knee and hip, is prone to contamination with various types of infections. Adding small amounts of different antibiotics to the cement can help prevent and treat infections.
Mohammad Reza Shafiei +3 more
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Enhanced Biofilm Disruption in Methicillin-Resistant Staphylococcus aureus Using Rifampin and Fluoroquinolone Combinations [PDF]
PathogensStaphylococcus aureus biofilms complicate the treatment of device-related infections. We hypothesized that combining rifampin with fluoroquinolones could eradicate biofilms even in antimicrobial-resistant S. aureus strains.
Yu Ri Kang +8 more
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A dose ranging trial to optimize the dose of Rifampin in the treatment of tuberculosis [PDF]
American Journal of Respiratory and Critical Care Medicine, 2015 The study was funded by the EDCTP (European & Developing Countries Clinical Trials Partnership), NACCAP (Netherlands-African partnership for Capacity development and Clinical interventions Against Poverty-related diseases) and the Bill & Melinda Gates ...
Aarnoutse, Rob E +18 more
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Frontiers in Pharmacology, 2016 Membrane drug transporters contribute to the disposition of many drugs. In human liver, drug transport is controlled by two main superfamilies of transporters, the solute carrier transporters (SLC) and the ATP Binding Cassette transporters (ABC). Altered
Eric A Benson +8 more
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Drug Design, Development and Therapy, 2017 Felix Greimel,1 Christine Scheuerer,1 Andre Gessner,2 Michaela Simon,2 Thomas Kalteis,1 Joachim Grifka,1 Achim Benditz,1 Hans-Robert Springorum,1 Jens Schaumburger1 1Department of Orthopedics, University Medical Center Regensburg, Asklepios ...
Greimel F +8 more
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