Results 1 to 10 of about 1,352,832 (329)
Effects of alcohol and PARP inhibition on RNA ribosomal engagement in cortical excitatory neurons. [PDF]
Front Mol Neurosci, 2023 We report on the effects of ethanol (EtOH) and Poly (ADP-ribose) polymerase (PARP) inhibition on RNA ribosomal engagement, as a proxy for protein translation, in prefrontal cortical (PFC) pyramidal neurons.
Krishnan HR +6 more
europepmc +3 more sources
Pre-Ribosomal RNA Processing in Human Cells: From Mechanisms to Congenital Diseases
Biomolecules, 2018 Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural scaffold and the catalytic center of protein synthesis in every living organism.
Maxime Aubert +3 more
doaj +2 more sources
Evidence for further non-coding RNA genes in the fungal rDNA region [PDF]
MycoKeys, 2022 Non-coding RNA (ncRNA) genes play important, but incompletely understood, roles in various cellular processes, notably translation and gene regulation.
Magnus Alm Rosenblad +5 more
doaj +3 more sources
Frontiers in Ecology and Evolution, 2015 It was Francis Crick who first asked why the ribosome contains so much RNA, and discussed the implications of this for the direct flow of genetic information from DNA to protein. Remarkable advances in our understanding of the ribosome and protein synthesis, including the recent publication of two mammalian mitochondrial ribosome structures, have shed ...
Harold S. Bernhardt, Warren P. Tate
openaire +2 more sources
Varying strength of selection contributes to the intragenomic diversity of rRNA genes
Nature Communications, 2022 Ribosomal RNA genes are abundant in eukaryotic genomes and code for the universal and essential RNA components of the ribosome. This study uncovers high sequence diversity of the genes within a single species and discusses the contribution of selection ...
Daniel Sultanov, Andreas Hochwagen
doaj +1 more source
Ribosomal control in RNA virus-infected cells
Frontiers in Microbiology, 2022 Viruses are strictly intracellular parasites requiring host cellular functions to complete their reproduction cycle involving virus infection of host cell, viral genome replication, viral protein translation, and virion release.
Xiao Wang +3 more
doaj +1 more source
Nature Communications, 2021 Early steps of large 60S ribosomal subunit biogenesis are not well understood. Here, the authors combine biochemical experiments with protein-RNA crosslinking and mass spectrometry to show that the RNA helicase Dbp7 is key player during early 60S ...
Gerald Ryan R. Aquino +9 more
doaj +1 more source
Ribosome Biogenesis in Archaea
Frontiers in Microbiology, 2021 Making ribosomes is a major cellular process essential for the maintenance of functional ribosome homeostasis and to ensure appropriate gene expression.
Paola Londei, Sébastien Ferreira-Cerca
doaj +1 more source
Mediating Ribosomal Competition by Splitting Pools [PDF]
LCSS Vol 5 Issue 5 (Nov 2020), 2020 Synthetic biology constructs often rely upon the introduction of "circuit" genes into host cells, in order to express novel proteins and thus endow the host with a desired behavior. The expression of these new genes "consumes" existing resources in the cell, such as ATP, RNA polymerase, amino acids, and ribosomes. Ribosomal competition among strands of
arxiv +1 more source
The mitochondrial ribosome and ribosomal RNA of the chick [PDF]
FEBS Letters, 1971 Reports have appeared on large molecular weight RNAs associated with the mitochondria of higher organisms. These include HeLa cells [ 1 ] , BHK-2 1 cells [2] , mouse L-cells [3,4] , rat liver [4, S] and Xenopus ovary [6] . This RNA consists of two predominant species found to be 17 S and 13 S by sedimentation [2, 31 .
Terence H. Rabbitts, T.S. Work
openaire +3 more sources