Results 1 to 10 of about 946,604 (388)
Extragenic accumulation of RNA polymerase II enhances transcription by RNA polymerase III. [PDF]
PLoS Genetics, 2007 Recent genomic data indicate that RNA polymerase II (Pol II) function extends beyond conventional transcription of primarily protein-coding genes. Among the five snRNAs required for pre-mRNA splicing, only the U6 snRNA is synthesized by RNA polymerase ...
Imke Listerman +3 more
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High resolution mapping of enhancer-promoter interactions. [PDF]
PLoS ONE, 2015 RNA Polymerase II ChIA-PET data has revealed enhancers that are active in a profiled cell type and the genes that the enhancers regulate through chromatin interactions. The most commonly used computational method for analyzing ChIA-PET data, the ChIA-PET
Christopher Reeder +5 more
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RNA polymerase II pausing in development: orchestrating transcription
Open Biology, 2022 The coordinated regulation of transcriptional networks underpins cellular identity and developmental progression. RNA polymerase II promoter-proximal pausing (Pol II pausing) is a prevalent mechanism by which cells can control and synchronize ...
Abderhman Abuhashem +2 more
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RNA polymerase II-associated proteins reveal pathways affected in VCP-related amyotrophic lateral sclerosis [PDF]
, 2023 Valosin-containing protein (VCP) is a hexameric ATPase associated with diverse cellular activities. Genetic mutations in VCP are associated with several forms of muscular and neuronal degeneration, including amyotrophic lateral sclerosis (ALS). Moreover,
Davey Karen +4 more
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RNA polymerase II at initiation [PDF]
Proceedings of the National Academy of Sciences, 2003 RNA polymerase II (RNAPII) is the enzyme responsible for synthesis of all mRNA in higher cells. As the central component of the eukaryotic transcription machinery, RNAPII is the final target of regulatory pathways that are ultimately responsible for cellular development, differentiation, and metabolic control.
Francisco J. Asturias, John L. Craighead
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Regulation of Eukaryotic RNAPs Activities by Phosphorylation
Frontiers in Molecular Biosciences, 2021 Evolutionarily conserved kinases and phosphatases regulate RNA polymerase II (RNAPII) transcript synthesis by modifying the phosphorylation status of the carboxyl-terminal domain (CTD) of Rpb1, the largest subunit of RNAPII.
Araceli González-Jiménez +5 more
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Genome-wide mapping of yeast RNA polymerase II termination. [PDF]
PLoS Genetics, 2014 Yeast RNA polymerase II (Pol II) terminates transcription of coding transcripts through the polyadenylation (pA) pathway and non-coding transcripts through the non-polyadenylation (non-pA) pathway.
Paul Schaughency +2 more
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A Movie of RNA Polymerase II Transcription [PDF]
Cell, 2012 We provide here a molecular movie that captures key aspects of RNA polymerase II initiation and elongation. To create the movie, we combined structural snapshots of the initiation-elongation transition and of elongation, including nucleotide addition, translocation, pausing, proofreading, backtracking, arrest, reactivation, and inhibition.
Cheung, A.C.M., Cramer, P.
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RNA Polymerase II: Just Stopping By [PDF]
Cell, 2007 In this issue of Cell, Guenther et al. (2007) analyze the presence of chromatin marks and RNA polymerase at transcription start sites in the human genome. Their results reveal that many "inactive" genes harbor histone marks associated with active transcription at their 5' ends and that although these genes initiate transcription, they do not generate ...
Dirk Schübeler, Matthew C. Lorincz
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A remodeled RNA polymerase II complex catalyzing viroid RNA-templated transcription.
PLoS Pathogens, 2022 Viroids, a fascinating group of plant pathogens, are subviral agents composed of single-stranded circular noncoding RNAs. It is well-known that nuclear-replicating viroids exploit host DNA-dependent RNA polymerase II (Pol II) activity for transcription ...
Shachinthaka D Dissanayaka Mudiyanselage +5 more
doaj +1 more source