Results 1 to 10 of about 122,915 (346)
Scleroderma with Nodular Scleroderma [PDF]
Case Reports in Dermatology, 2016 Background: Nodular scleroderma is a rare variant of scleroderma which can occur in connection with systemic sclerosis or morphea. A biopsy from the lesion can demonstrate the scleroderma pattern, i.e., keloid pattern or mixed type.
Chutika Srisuttiyakorn +1 more
doaj +3 more sources
Frontiers in Immunology, 2019 Systemic sclerosis is a profibrotic autoimmune disease mediated by the dysregulation of extracellular matrix synthesis. Formyl peptide receptor 2 (Fpr2) is a G protein-coupled receptor that modulates inflammation and host defense by regulating the ...
Gyu Tae Park +7 more
doaj +2 more sources
CD47 prevents the elimination of diseased fibroblasts in scleroderma
JCI Insight, 2020 Scleroderma is a devastating fibrotic autoimmune disease. Current treatments are partly effective in preventing disease progression but do not remove fibrotic tissue.
Tristan Lerbs +9 more
doaj +2 more sources
Scleroderma and scleroderma-like syndromes
Frontiers in ImmunologySystemic sclerosis is a systemic connective tissue disease whose main pathophysiological mechanism is a progressive fibrosis of internal organs and skin leading to thickening and induration. Blood vessels may also be involved.
Katarzyna Romanowska-Próchnicka +4 more
doaj +3 more sources
AIMS Allergy and Immunology, 2021 Toll-like receptors (TLRs) are essential defensive mediators implicated in immune diseases. Tight regulation of TLR function is indispensable to avoid the damaging effects of chronic signaling.
Swarna Bale +2 more
doaj +1 more source
Infections of scleroderma digital ulcers: a single center cohort retrospective study
Dermatology Reports, 2021 BACKGROUNDS: Systemic Sclerosis (SSc) is a complex autoimmune and up to fifty percent of patients develop digital ulcers. AIMS: Understand how much infections influence scleroderma digital ulcers’ healing.
Dilia Giuggioli +7 more
doaj +1 more source
Pathophysiology of systemic sclerosis (scleroderma)
Kaohsiung Journal of Medical Sciences, 2022 Systemic sclerosis (scleroderma) is an autoimmune‐triggered chronic fibrosing disease that affects the skin and many other organs. Its pathophysiology is complex and involves an early endothelial damage, an inflammatory infiltrate and a resulting ...
A. Rosendahl, K. Schönborn, T. Krieg
semanticscholar +1 more source
Systemic Scleroderma—Definition, Clinical Picture and Laboratory Diagnostics
Journal of Clinical Medicine, 2022 (1) Background: Scleroderma (Sc) is a rare connective tissue disease classified as an autoimmune disorder. The pathogenesis of this disease is not fully understood. (2) Methods: This article reviews the literature on systemic scleroderma (SSc).
Anna Kowalska-Kępczyńska
semanticscholar +1 more source
A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]
, 2015 In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Abraham, D +11 more
core +12 more sources
Pharmaceuticals, 2022 The role of Bronchoalveolar Lavage (BAL) in the evaluation of systemic sclerosis (SSc) interstitial lung disease (ILD) is still controversial. The aim of this systematic literature review was to investigate the use of BAL in SSc-ILD, and to focus on the ...
Martina Orlandi +8 more
doaj +1 more source