Simulated Weightlessness Perturbs the Intestinal Metabolomic Profile of Rats [PDF]
Frontiers in Physiology, 2019 Recently, disorders of intestinal homeostasis in the space environment have been extensively demonstrated. Accumulating evidence have suggested microgravity and simulated weightlessness could induce dysbiosis of intestinal microbiota, which may ...
Mingliang Jin +5 more
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Choroidal circulation disturbance is an initial factor in outer retinal degeneration in rats under simulated weightlessness [PDF]
Frontiers in Physiology, 2023 Objective: Microgravity contributes to ocular injury yet the underlying mechanism remains unclear. This study aims to elucidate the mechanism behind choroidal circulation disorder and outer retinal degeneration in rats with simulated weightlessness ...
Yuxue Mu +10 more
doaj +5 more sources
Simulated weightlessness procedure, head-down bed rest has reversible effects on the metabolism of rhesus macaque [PDF]
Molecular BrainIt is a consensus in the international manned space field that factors such as microgravity during the space flight can cause anxiety, depression and other important brain function abnormalities in astronauts.
Yuting Li +16 more
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Dynamic Changes in Hindlimb Motor Cortex Neurons during Simulated Weightlessness Revealed by Miniature 2-Photon Microscopy [PDF]
ResearchDysfunction of motor behavior during spaceflight is linked to alterations in neuronal activities. However, the longitudinal functional changes in the motor cortex triggered by simulated weightlessness remain ambiguous.
Yuanyuan Fan +18 more
doaj +4 more sources
Dammarane Sapogenins Improving Simulated Weightlessness-Induced Depressive-Like Behaviors and Cognitive Dysfunction in Rats [PDF]
Frontiers in Psychiatry, 2021 Background: Our studies demonstrated that the space environment has an impact on the brain function of astronauts. Numerous ground-based microgravity and social isolation showed that the space environment can induce brain function damages in humans and ...
Qiong Wang +16 more
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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions [PDF]
Neural Regeneration ResearchA microgravity environment has been shown to cause ocular damage and affect visual acuity, but the underlying mechanisms remain unclear. Therefore, we established an animal model of weightlessness via tail suspension to examine the pathological changes ...
Yuxue Mu +9 more
doaj +4 more sources
Simulated weightlessness procedure, head-down bed rest impairs adult neurogenesis in the hippocampus of rhesus macaque [PDF]
Molecular Brain, 2019 The microgravity environment in space can impact astronauts’ cognitive and behavioral activities. However, due to the limitations of research conditions, studies of biological changes in the primate brain, such as neurogenesis, have been comparatively ...
Xu Zhang +10 more
doaj +5 more sources
Numerical analysis of blood flow in the abdominal aorta under simulated weightlessness and earth conditions [PDF]
Scientific ReportsBlood flow through the abdominal aorta and iliac arteries is a crucial area of research in hemodynamics and cardiovascular diseases. To get in to the problem, this study presents detailed analyses of blood flow through the abdominal aorta, together with ...
Marta Żyłka +3 more
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Responses of Intestinal Mucosal Barrier Functions of Rats to Simulated Weightlessness [PDF]
Frontiers in Physiology, 2018 Exposure to microgravity or weightlessness leads to various adaptive and pathophysiological alterations in digestive structures and physiology. The current study was carried out to investigate responses of intestinal mucosal barrier functions to ...
Mingliang Jin +7 more
doaj +5 more sources
Influence of Social Isolation During Prolonged Simulated Weightlessness by Hindlimb Unloading [PDF]
Frontiers in Physiology, 2019 The hindlimb unloading (HU) model has been used extensively to simulate the cephalad fluid shift and musculoskeletal disuse observed in spaceflight with its application expanding to study immune, cardiovascular and central nervous system responses, among
Candice G. T. Tahimic +18 more
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