Results 51 to 60 of about 2,871 (258)
Proprioceptive and Kinesthetic Feedback for Robotic Manipulation [PDF]
, 2019 Programming robots to manipulate general objects in unstructured, human-centric environments is a complex problem. Typical assumptions for engineering-based solutions to manipulation are that the object can be recognized, that it is nearly rigid, and ...
Leontie, Roxana
core
Vibrotactile feedback in m-commerce:Stimulating perceived control and perceived ownership to increase anticipated satisfaction [PDF]
Consumers increasingly purchase through m-channels, including apps. Accordingly, marketers have enhanced immersive, sensorial aspects of m-channels, such as including vibrations while making in-app purchases. Given discrepant findings, it remains unclear
Yazdanparast Ardestani, Atefeh +6 more
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Human factors considerations for ultrasound induced mid-air haptic feedback [PDF]
, 2022 The engineering design process can be complex and often involves reiteration of design activities in order to improve outcomes. Traditionally, the design process consists of many physical elements, for example, clay/foam modelling and more recently ...
Khan, James
core +3 more sources
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
User-centered extension of a locomotion typology: Movement-related sensory feedback and spatial learning [PDF]
, 2019 © 2019 IEEE. When human operators locomote actively in virtual environments (VE), the movement range often has to be adapted to the limited dimensions of the physical space.
Carolin Wienrich +7 more
core +1 more source