Results 51 to 60 of about 901,469 (254)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Estudio comparativo del perfil sensorial en niños de 4 a 10 años de la ciudad de Quito vs. perfil sensorial de niños con autismo de la fundación entra a mi mundo en el primer semestre de 2016 [PDF]

, 2016
El perfil sensorial se convierte en un pilar fundamental para el desarrollo y progreso del niño. Este estudio compara e identifica las características del perfil sensorial de niños con autismo y un grupo de niños sin autismo, el informe de los padres de ...
Herrmann Enríquez, Ana Carolina
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

FEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey, Vaishnavi Sanjayan, Praveen Singh, Shantanu Sengupta, Anand Kumar Bachhawat   +4 more
wiley   +1 more source

Architects need environmental feedback [PDF]

, 2004
The role of environmental feedback within architects' offices is examined as a fundamental ingredient of sustainability. Three case study buildings are examined using a feedback exercise encompassing the whole building process from early key design ...
Andreu, IC, Isabel Carmona Andreu, Tadj Oreszczyn, Oreszczyn, T   +3 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Sensorial characterization of white-corn Zea mays L and its final product arepa type Antioquia

, 2014
RESUMEN: La arepa de Colombia es un alimento de apariencia plana y delgada, elaborada a partir de maíz blanco (Zea Mayz L) trillado. Se realizó estudio de caracterización sensorial de maíz blanco y arepa tipo tela con jueces entrenados del Laboratorio de
Ardila Castañeda, Maurem Paola, García Betancur, Alba Yamile, Martínez Álvarez, Olga Lucía   +2 more
core  

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

On the Sensorial of Imagination

, 2019
The senses appear on the boundary between the inside and the outside of human experience. They are like an open door through which light, impres-sions, and air enter, are exchanged, and merge with the light, impressions, and air that were there before ...
Coessens, Kathleen, Tomlinson, Vanessa
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source