Results 161 to 170 of about 289,950 (199)

Multiplex Community Detection in Social Networks Using a Chaos‐Based Hybrid Evolutionary Approach [PDF]

Bagher Zarei, Bahman Arasteh, Mehdi Asadi, Vahid Majidnezhad, Saeid Taghavi Afshord, Asgarali Bouyer   +5 more
openalex   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source

Adult Influenza Patients Diagnosed by Multiplex Polymerase Chain Reaction Tests, but Not Rapid Antigen Tests, and Managed Successfully During the 2024 to 2025 Major Influenza-Endemic Season in a Tertiary Hospital in Japan. [PDF]

Infect Drug Resist
Seki M.
europepmc   +1 more source

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Impact of molecular point-of-care testing for respiratory pathogens on antibiotic use and clinical outcomes in acute respiratory tract infections: a systematic review and meta-analysis. [PDF]

EClinicalMedicine
Li Q, Zhou Q, Fan J, Feng X, Lai H, Chen Y, Ye Z, Song F, Liu J, Chen D, Kang R, Tang D, Teboul JL, Timsit JF, Torres A, De Waele JJ, Carratalà J, Jiang J, Luo Z, Zeng L.   +19 more
europepmc   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Molecular and biochemical correlates of frontal lobe white matter degeneration in humans with alcohol use disorder. [PDF]

Adv Drug Alcohol Res
de la Monte SM, Tong M, Sutherland G.
europepmc   +1 more source

Engineered TIGIT‐Blockade Membrane Vesicles Synergize with Microwave Ablation to Mediate Liver Metastases Eradication

Advanced Science, EarlyView.
Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li, Weichen Xu, Yuting Shen, Xuexia Shan, Jiawei Sun, Shisi Ding, Xiaodong Hou, Shaoning Zhang, Zhiyuan Niu, Taixia Wang, Xin Guan, Xiao Li, Weiwei Ren, Dou Du, Huixiong Xu, Wenwen Yue, Liping Sun   +16 more
wiley   +1 more source

Technical validation and implementation of a multiplex real-time PCR for differential diagnostic detection of Zika virus, yellow fever virus, dengue virus and chikungunya virus (ZYDC-PCR). [PDF]

BMC Infect Dis
Hauner A, Benítez AJ, Mulopo-Mukanya N, Rogé S, Serrano S, Vanlerberghe V, Lepore L, Esbroeck MV, Masumu J, Nasimiyu C, Njenga MK, Romani MET, Portal YV, Álvarez M, Ramírez-Bartutis R, Guzmán MG, Ahuka-Mundeke S, Mukadi-Bamuleka D, Ariën KK.   +18 more
europepmc   +1 more source